Product References
Low-density lipoprotein balances T cell metabolism and enhances response to anti-PD-1 blockade in a HCT116 spheroid model.
Frontiers in oncology
Babl N,Hofbauer J,Matos C,Voll F,Menevse AN,Rechenmacher M,Mair R,Beckhove P,Herr W,Siska PJ,Renner K,Kreutz M,Schnell A
Published figure using CD223 (LAG-3) monoclonal antibody (Product # 46-2239-42) in Flow Cytometry
Tue Feb 14 00:00:00 EST 2023
RASA2 ablation in T cells boosts antigen sensitivity and long-term function.
Nature
Carnevale J,Shifrut E,Kale N,Nyberg WA,Blaeschke F,Chen YY,Li Z,Bapat SP,Diolaiti ME,O'Leary P,Vedova S,Belk J,Daniel B,Roth TL,Bachl S,Anido AA,Prinzing B,Ibañez-Vega J,Lange S,Haydar D,Luetke-Eversloh M,Born-Bony M,Hegde B,Kogan S,Feuchtinger T,Okada H,Satpathy AT,Shannon K,Gottschalk S,Eyquem J,Krenciute G,Ashworth A,Marson A
46-2239-42 was used in Flow cytometry/Cell sorting to highlight RASA2 as a promising target to enhance both persistence and effector function in T cell therapies for cancer treatment.
Thu Sep 01 00:00:00 EDT 2022
CD4+ LAG-3+ T cells are decreased in active psoriatic arthritis patients and their restoration in vitro is mediated by TNF inhibitors.
Clinical and experimental immunology
Gertel S,Polachek A,Furer V,Levartovsky D,Elkayam O
Published figure using CD223 (LAG-3) monoclonal antibody (Product # 46-2239-42) in Flow Cytometry
Mon Nov 01 00:00:00 EDT 2021
Bispecific T-Cell Engaging Antibodies Against MUC16 Demonstrate Efficacy Against Ovarian Cancer in Monotherapy and in Combination With PD-1 and VEGF Inhibition.
Frontiers in immunology
Yeku OO,Rao TD,Laster I,Kononenko A,Purdon TJ,Wang P,Cui Z,Liu H,Brentjens RJ,Spriggs D
Published figure using CD223 (LAG-3) monoclonal antibody (Product # 46-2239-42) in Flow Cytometry
Thu Oct 21 00:00:00 EDT 2021
Senolytic CAR T cells reverse senescence-associated pathologies.
Nature
Amor C,Feucht J,Leibold J,Ho YJ,Zhu C,Alonso-Curbelo D,Mansilla-Soto J,Boyer JA,Li X,Giavridis T,Kulick A,Houlihan S,Peerschke E,Friedman SL,Ponomarev V,Piersigilli A,Sadelain M,Lowe SW
46-2239 was used in Flow cytometry/Cell sorting to establish the therapeutic potential of senolytic CAR T cells for senescence-associated diseases.
Wed Jul 01 00:00:00 EDT 2020
MAVS Genetic Variation Is Associated with Decreased HIV-1 Replication In Vitro and Reduced CD4+ T Cell Infection in HIV-1-Infected Individuals.
Viruses
Stunnenberg M,van Pul L,Sprokholt JK,van Dort KA,Gringhuis SI,Geijtenbeek TBH,Kootstra NA
Published figure using CD223 (LAG-3) monoclonal antibody (Product # 46-2239-42) in Flow Cytometry
Thu Jul 16 00:00:00 EDT 2020
Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma.
Nature communications
Hegde M,Joseph SK,Pashankar F,DeRenzo C,Sanber K,Navai S,Byrd TT,Hicks J,Xu ML,Gerken C,Kalra M,Robertson C,Zhang H,Shree A,Mehta B,Dakhova O,Salsman VS,Grilley B,Gee A,Dotti G,Heslop HE,Brenner MK,Wels WS,Gottschalk S,Ahmed N
Published figure using CD223 (LAG-3) monoclonal antibody (Product # 46-2239-42) in Flow Cytometry
Wed Jul 15 00:00:00 EDT 2020
Divergent LAG-3 versus BTLA, TIGIT, and FCRL3 expression in Sézary syndrome.
Leukemia & lymphoma
Anzengruber F,Ignatova D,Schlaepfer T,Chang YT,French LE,Pascolo S,Contassot E,Bobrowicz M,Hoetzenecker W,Guenova E
Published figure using CD223 (LAG-3) monoclonal antibody (Product # 46-2239-42) in Flow Cytometry
Thu Aug 01 00:00:00 EDT 2019
Effect of analytical treatment interruption and reinitiation of antiretroviral therapy on HIV reservoirs and immunologic parameters in infected individuals.
PLoS pathogens
Clarridge KE,Blazkova J,Einkauf K,Petrone M,Refsland EW,Justement JS,Shi V,Huiting ED,Seamon CA,Lee GQ,Yu XG,Moir S,Sneller MC,Lichterfeld M,Chun TW
46-2239 was used in Flow cytometry/Cell sorting to evaluate if there's a correlation between analytical treatment interruption of ART in HIV patients, and the size of the persistent HIV reservoir.
Mon Jan 01 00:00:00 EST 2018
Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection.
Nature
Eyquem J,Mansilla-Soto J,Giavridis T,van der Stegen SJ,Hamieh M,Cunanan KM,Odak A,Gönen M,Sadelain M
46-2239 was used in Flow cytometry/Cell sorting to demonstrate that targeting a chimeric antigen receptor coding sequence to the TCR locus increases the therapeutic potency of engineered T cells.
Thu Mar 02 00:00:00 EST 2017
Targeted reconstruction of T cell receptor sequence from single cell RNA-seq links CDR3 length to T cell differentiation state.
Nucleic acids research
Afik S,Yates KB,Bi K,Darko S,Godec J,Gerdemann U,Swadling L,Douek DC,Klenerman P,Barnes EJ,Sharpe AH,Haining WN,Yosef N
46-2239 was used in Flow cytometry/Cell sorting to show that naive-like memory T cells have significantly longer CDR3 regions and greater divergence from germline state than effector-memory cells.
Tue Sep 19 00:00:00 EDT 2017
OMIP-037: 16-color panel to measure inhibitory receptor signatures from multiple human immune cell subsets.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Belkina AC,Snyder-Cappione JE
Published figure using CD223 (LAG-3) monoclonal antibody (Product # 46-2239-42) in Flow Cytometry
Wed Feb 01 00:00:00 EST 2017
Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection.
Nature communications
Miles B,Miller SM,Folkvord JM,Kimball A,Chamanian M,Meditz AL,Arends T,McCarter MD,Levy DN,Rakasz EG,Skinner PJ,Connick E
Published figure using CD223 (LAG-3) monoclonal antibody (Product # 46-2239-42) in Flow Cytometry
Tue Oct 20 00:00:00 EDT 2015
Immunological biomarkers predict HIV-1 viral rebound after treatment interruption.
Nature communications
Hurst J,Hoffmann M,Pace M,Williams JP,Thornhill J,Hamlyn E,Meyerowitz J,Willberg C,Koelsch KK,Robinson N,Brown H,Fisher M,Kinloch S,Cooper DA,Schechter M,Tambussi G,Fidler S,Babiker A,Weber J,Kelleher AD,Phillips RE,Frater J
46-2239 was used in Flow cytometry/Cell sorting to show that immunological biomarkers can predict time to viral rebound after stopping antiretroviral therapy.
Fri Oct 09 00:00:00 EDT 2015