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Invitrogen
5-Fluorouracil Recombinant Mouse Monoclonal Antibody (3C12)
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5-Fluorouracil Antibody (MA566656) in SDS-PAGE
SDS-PAGE characterization of 5-Fluorouracil under reducing conditions. Lane M: Protein marker (kDa); Lane 5-FU: Purified 5-Fluorouracil Recombinant Monoclonal (Product # MA566656). 5-Fluorouracil showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-335.
产品信息
MA566656
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
3C12
抗原
Conjugate of 5-FU hapten and KLH.
偶联物
形式
Liquid
浓度
6.5 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
5-Fluorouracil (5-FU) is a widely used chemotherapeutic agent primarily employed in the treatment of colorectal cancer, among other types of cancer. It functions as an antimetabolite, interfering with the synthesis of DNA and RNA by inhibiting the enzyme thymidylate synthase, which is crucial for DNA replication. The gene location and structure of 5-FU are not directly applicable as it is a synthetic compound, but its mechanism of action involves the incorporation into RNA and DNA, disrupting normal cellular processes. Despite its efficacy, 5-FU is associated with challenges such as drug resistance, low bioavailability, and rapid metabolism, prompting the development of innovative delivery systems to enhance its therapeutic effects. Research continues to explore strategies to overcome these limitations, including nano-delivery systems and combination therapies to improve its anticancer activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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