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5HT2A Receptor (HTR2A) (extracellular) Polyclonal Antibody

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5HT2A Receptor (HTR2A) (extracellular) Polyclonal Antibody

产品信息

ASR-033-200UL

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:200
-

免疫组化（冰冻） (IHC (F))

1:120
-

流式细胞分析 (Flow)

5 µg
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

(C)SEASNWTIDAENR, corresponding to amino acid residues 40-52 of rat 5-Hydroxytryptamine receptor 2A, Extracellular, N-terminus
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.9 mg/mL

规格

180 µg

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 1% BSA

内含物

0.05% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).

靶标信息

In platelets and gut, serotonin plays a major role in cardiovascular function and motility of the gastrointestinal tract, respectively. Serotonin mediates its effects through several of G protein coupled receptors, designated 5-HT receptors or alternatively SR receptors. The SR-2 receptors are comprised of three subtypes, SR-2A, SR-2B and SR-2C, which activate phospholipase C and release intracellular stores of calcium in response to serotonin. SR-2A has a specific role in tracheal smooth muscle contraction, bronchoconstriction and mediating aldosterone production, and it is also thought to play a role in several psychiatric disorders, including depression and schizophrenia. SR-2B is expressed in embryonic and adult cardiovascular tissues, gut and brain and plays an important role in the pathology of cardiac disorders. SR-2C is thought to mediate the effects of atypical antipsychotic drugs.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: 5-HT-2; 5-HT-2A; 5-HT2 receptor; 5-HT2A receptor; 5-HT2A/2C; 5-HT2A/2C receptor; 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled; 5-hydroxytryptamine 2 receptor; 5-hydroxytryptamine receptor 2A; 5HT2A Receptor; serotonin 5-HT-2A receptor; serotonin 5HT-2 receptor; serotonin receptor; Serotonin receptor 2A; SR2A; unnamed protein product

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基因别名: 5-HT2A; 5Ht-2; E030013E04; Htr-2; HTR2; HTR2A

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UniProt ID: (Human) P28223, (Mouse) P35363, (Rat) P14842

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Entrez Gene ID: (Human) 3356, (Mouse) 15558, (Rat) 29595

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功能
Gq/11-coupled serotonin receptor activity virus receptor activity G-protein coupled receptor activity G-protein coupled serotonin receptor activity protein binding protein tyrosine kinase activator activity neurotransmitter receptor activity identical protein binding macromolecular complex binding serotonin binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding serotonin receptor activity G-protein alpha-subunit binding signal transducer activity drug binding protein complex binding G-protein coupled receptor
参与通路
temperature homeostasis positive regulation of cytokine production involved in immune response glycolytic process cellular calcium ion homeostasis signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger positive regulation of cytosolic calcium ion concentration phospholipase C-activating serotonin receptor signaling pathway serotonin receptor signaling pathway chemical synaptic transmission memory positive regulation of cell proliferation response to xenobiotic stimulus positive regulation of phosphatidylinositol biosynthetic process regulation of dopamine secretion artery smooth muscle contraction urinary bladder smooth muscle contraction positive regulation of heat generation response to cocaine negative regulation of potassium ion transport positive regulation of neuron apoptotic process protein localization to cytoskeleton positive regulation of fat cell differentiation positive regulation of glycolytic process positive regulation of vasoconstriction viral entry into host cell sensitization behavioral response to cocaine positive regulation of inflammatory response sensory perception of temperature stimulus detection of temperature stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception of pain release of sequestered calcium ion into cytosol negative regulation of synaptic transmission, glutamatergic positive regulation of ERK1 and ERK2 cascade G protein-coupled serotonin receptor signaling pathway presynaptic modulation of chemical synaptic transmission positive regulation of execution phase of apoptosis positive regulation of platelet aggregation positive regulation of DNA biosynthetic process smooth muscle contraction activation of phospholipase C activity behavior cell death phosphatidylinositol 3-kinase signaling sensory perception of pain sleep positive regulation of kinase activity response to drug positive regulation of MAP kinase activity regulation of hormone secretion positive regulation of peptidyl-tyrosine phosphorylation regulation of behavior aging
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