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Proteintech
CXCR3B Monoclonal Antibody (1B2D6)
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产品信息
60065-1-IG
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
1B2D6
抗原
Peptide
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
150 µg
纯化类型
Protein A
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.1% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This monoclonal antibody is specific to CXCR3B.
靶标信息
Chemokines play important roles in inflammation and critical for the recruitment of effector immune cells to sites of infection. Historically, CD183 was the third CXC chemokine receptor discovered and therefore, commonly designated as CXCR3. Binding of chemokines to CD183 induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. The CXC chemokine receptor (CXCR) 3, a G-protein-coupled 7-transmembrane receptor, is expressed at high levels on activated and memory T cells, B cells, natural killer cells, and plasmacytoid monocytes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: C-X-C chemokine receptor type 3; CD183; chemokine (C-X-C motif) receptor 3; chemokine (C-X-C motif) receptor 3 isoform CXCR3_1; chemokine (C-X-C motif) receptor 3 isoform CXCR3_2; chemokine receptor 3; CKR-L2; CXC-R3; CXCR3-B; G protein-coupled receptor; G protein-coupled receptor; G protein-coupled receptor 9; Interferon-inducible protein 10 receptor; IP-10 receptor; Mig receptor; unnamed protein product
基因别名: CD182; CD183; CKR-L2; CMKAR3; CXCR3; GPR9; IP10-R; Mig-R; MigR
UniProt ID: (Human) P49682
Entrez Gene ID: (Human) 2833
angiogenesis
negative regulation of endothelial cell proliferation
regulation of leukocyte migration
apoptotic process
chemotaxis
inflammatory response
immune response
cell adhesion
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
positive regulation of cell proliferation
T cell chemotaxis
negative regulation of angiogenesis
calcium-mediated signaling
regulation of cell adhesion
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
positive regulation of chemotaxis
positive regulation of release of sequestered calcium ion into cytosol
cell chemotaxis
chemokine-mediated signaling pathway
negative regulation of execution phase of apoptosis
positive regulation of execution phase of apoptosis
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