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Proteintech
CD41 Monoclonal Antibody (MWReg30)
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FIGURE: 1 / 1
CD41 Antibody (65189-1-IG) in Flow
1x10^6 C57BL/6 mouse peripheral blood platelets were surface stained with 0.5 µg Anti-Mouse CD41 (65189-1-Ig, Clone: MWReg30) and FITC anti-rat IgG1 Antibody (red), or 0.5 µg Rat IgG1 Isotype Control (HRPN) (65212-1-Ig, Clone: HRPN) and FITC anti-rat IgG1 Antibody (blue). Cells were not fixed.
Product Details
65189-1-IG
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
MWReg30
Immunogen
Mouse platelets
Conjugate
Form
Liquid
Purification
Protein G
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Wet ice
Target Information
CD41, also known as platelet glycoprotein IIb or ITGA2B, is a protein composed of two subunits: a 120 kDa alpha subunit and a 23 kDa beta subunit. It interacts with CD61 (gpIIIa, integrin beta III) in the presence of calcium to form a functional adhesive protein receptor. Initially thought to be expressed exclusively on platelets and megakaryocytes, CD41 is also found on hematopoietic progenitors in the embryo, fetus, and adult, indicating its role in early stages of hematopoietic differentiation. CD41 plays a crucial role in platelet function and blood coagulation by mediating platelet aggregation. Upon blood vessel damage, CD41 binds to various adhesion molecules, including von Willebrand factor, fibrinogen, fibronectin, and vitronectin, facilitating platelet adhesion and aggregation. This receptor is essential for platelet function, contributing to the binding of several adhesion molecules and playing a significant role in hemostasis. Diseases associated with CD41 dysfunction include Glanzmann Thrombasthenia and Platelet type-16 bleeding disorder, highlighting its importance in normal platelet function and blood coagulation processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha IIb; CD41; form 1; form 2; GP IIb; GPalpha IIb; GPIIb; Integrin alpha-IIb; platelet glycoprotein IIb of IIb/II Ia complex; Platelet membrane glycoprotein IIb
Gene Aliases: AI172977; alphaIIb; CD41; CD41B; GpIIb; Itga2b
UniProt ID: (Mouse) Q9QUM0
Entrez Gene ID: (Mouse) 16399
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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