Proteintech

CNOT1 Monoclonal Antibody (1A10A11)

Name: CNOT1 Monoclonal Antibody (1A10A11)
Brand: Proteintech
SKU: 66507-1-IG

4 篇参考文献

查看其他8个CNOT1抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (9)

CNOT1 Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 9

CNOT1 Antibody (66507-1-IG) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol) fixed HepG2 cells using 66507-1-IG (CNOT1 antibody) at dilution of 1:100 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Mouse IGG (H+L).

CNOT1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Immunogen image

Immunogen Image CNOT1 Monoclonal Antibody (1A10A11)

产品信息

66507-1-IG

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

查看3篇已发表文章 3篇已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:500

免疫细胞化学 (ICC/IF)

1:50-1:500

查看1篇已发表文章 1篇已发表文章

产品规格

种属反应

Human, Mouse, Pig, Rat

已发表种属

Mouse

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

1A10A11

抗原

CNOT1 Fusion Protein Ag5623 (1-354 aa encoded by BC040523)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein G

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

This is a rabbit polyclonal antibody raised against a region from the C-terminal CNOT1 of human origin. CNOT1 exists as many isoforms. Isoform one is about 267 kDa and isoform four is about 173 kDa.

Immunogen sequence: MNLDSLSLA LSQISYLVDN LTKKNYRASQ QEIQHIVNRH GPEADRHLLR CLFSHVDFSG DGKSSGKDFH QTQFLIQECA LLITKPNFIS TLSYAIDNPL HYQKSLKPAP HLFAQLSKVL KLSKVQEVIF GLALLNSSSS DLRGFAAQFI KQKLPDLLRS YIDADVSGNQ EGGFQDIAIE VLHLLLSHLL FGQKGAFGVG QEQIDAFLKT LRRDFPQERC PVVLAPLLYP EKRDILMDRI LPDSGGVAKT MMESSLADFM QEVGYGFCAS IEECRNIIVQ FGVREVTAAQ VARVLGMMAR THSGLTDGIP LQSISAPGSG IWSDGKDKSD GAQAHTWNVE VLIDVLKELN PSLNF (1-354 aa encoded by BC040523)

靶标信息

Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity. [UniProt]

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: adrenal gland protein AD-005; CCR4-associated factor 1; CCR4-NOT transcription complex subunit 1; CCR4-NOT transcription complex, subunit 1; Negative regulator of transcription subunit 1 homolog; NOT1 (negative regulator of transcription 1, yeast) homolog; NOT1H

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基因别名: 6030411K04Rik; AA815922; AD-005; CDC39; CNOT1; D830048B13; KIAA1007; NOT1; NOT1H; RGD1308009

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UniProt ID: (Human) A5YKK6, (Mouse) Q6ZQ08

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Entrez Gene ID: (Pig) 100511993, (Human) 23019, (Rat) 291841, (Mouse) 234594

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