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TNFAIP3 Monoclonal Antibody (3A11G6)

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TNFAIP3 Monoclonal Antibody (3A11G6)

产品信息

66695-1-IG

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000-1:6,000
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免疫组化 (IHC)

-
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免疫细胞化学 (ICC/IF)

1:50-1:500
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产品规格

种属反应

Human, Rat

已发表种属

Human, Mouse

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

3A11G6

抗原

TNFAIP3 Fusion Protein Ag18150 (441-790 aa encoded by BC114480)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein G

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: EAYEPLAWN PEESTGGPHS APPTAPSPFL FSETTAMKCR SPGCPFTLNV QHNGFCERCH NARQLHASHA PDHTRHLDPG KCQACLQDVT RTFNGICSTC FKRTTAEASS SLSTSLPPSC HQRSKSDPSR LVRSPSPHSC HRAGNDAPAG CLSQAARTPG DRTGTSKCRK AGCVYFGTPE NKGFCTLCFI EYRENKHFAA ASGKVSPTAS RFQNTIPCLG RECGTLGSTM FEGYCQKCFI EAQNQRFHEA KRTEEQLRSS QRRDVPRTTQ STSRPKCARA SCKNILACRS EELCMECQHP NQRMGPGAHR GEPAPEDPPK QRCRAPACDH FGNAKCNGYC NECFQFKQMY G (441-790 aa encoded by BC114480)

靶标信息

TNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas. Recently, it was identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-a, inhibiting NF-kappa-B-dependent gene expression, and protecting cells from TNF-a-cytotoxicity. Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting that TNFAIP3 also acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful over-responses to pathogens. At least two isoforms of TNFAIP3 are known to exist.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: OTU domain-containing protein 7C; Putative DNA-binding protein A20; RP11-356I2.3; TNF alpha-induced protein 3; TNFAIP3 (A20); Tumor necrosis factor alpha-induced protein 3; tumor necrosis factor inducible protein A20; tumor necrosis factor, alpha induced protein 3; tumor necrosis factor, alpha-induced protein 3; Zinc finger protein A20

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基因别名: A20; AISBL; OTUD7C; TNFA1P2; TNFAIP3

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UniProt ID: (Human) P21580

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Entrez Gene ID: (Human) 7128, (Rat) 683206

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功能
protease binding DNA binding ubiquitin-protein transferase activity thiol-dependent ubiquitin-specific protease activity protein binding zinc ion binding ligase activity kinase binding ubiquitin binding protein self-association K63-linked polyubiquitin binding cysteine protease
参与通路
B-1 B cell homeostasis response to molecule of bacterial origin regulation of germinal center formation negative regulation of chronic inflammatory response apoptotic process inflammatory response regulation of tumor necrosis factor-mediated signaling pathway protein deubiquitination negative regulation of protein ubiquitination negative regulation of NF-kappaB transcription factor activity negative regulation of type I interferon production response to muramyl dipeptide negative regulation of interleukin-1 beta production negative regulation of interleukin-2 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production negative regulation of toll-like receptor 2 signaling pathway negative regulation of toll-like receptor 3 signaling pathway negative regulation of toll-like receptor 4 signaling pathway negative regulation of toll-like receptor 5 signaling pathway protein K11-linked deubiquitination negative regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of protein catabolic process negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of bone resorption negative regulation of innate immune response negative regulation of smooth muscle cell proliferation regulation of defense response to virus by host regulation of inflammatory response negative regulation of inflammatory response negative regulation of B cell activation protein oligomerization regulation of vascular wound healing cellular response to hydrogen peroxide nucleotide-binding oligomerization domain containing signaling pathway negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway protein K63-linked deubiquitination protein K48-linked ubiquitination protein K48-linked deubiquitination cellular response to lipopolysaccharide protein deubiquitination involved in ubiquitin-dependent protein catabolic process tolerance induction to lipopolysaccharide establishment of protein localization to vacuole negative regulation of osteoclast proliferation negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of cellular protein catabolic process positive regulation of hepatocyte proliferation negative regulation of CD40 signaling pathway negative regulation of endothelial cell apoptotic process negative regulation of cell death
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