Proteintech

ACVR1 Monoclonal Antibody (1F11B10)

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产品信息

67417-1-IG

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:3,000
查看1篇已发表文章 1篇已发表文章

免疫组化（石蜡） (IHC (P))

1:300
-
产品规格

种属反应

Human, Mouse, Pig, Rat

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

1F11B10

抗原

ACVR1 Fusion Protein Ag13508

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1000 µg/mL

纯化类型

Protein A

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

产品详细信息

Aliquoting is unnecessary for -20°C storage.

靶标信息

Activin A receptor, type I (ACVR1) belongs to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. ACVR1 signals a specific transcriptional response in concert with activin type II receptors. The ACVR1 gene encodes activin A type I receptor, which signals a particular transcriptional response in concert with activin type II receptors. Mutations in ACVR1 have been linked to Fibrodysplasia Ossificans Progressiva (FOP), a rare genetic disorder characterized by the formation of bone in muscles, tendons, and other connective tissues, as well as Epicanthus.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: activin A receptor type I; activin A receptor, type 1; activin A receptor, type I; activin A receptor, type II-like kinase 2; Activin receptor type I; Activin receptor type-1; Activin receptor-like kinase 2; activin type I receptor; ACTR-I; ALK-2; ALK2-B; hydroxyalkyl-protein kinase; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSK-7L; TSR-I

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基因别名: ActR-I; ACTRI; ActRIA; Acvr; ACVR1; ACVR1A; ACVRLK2; Alk-2; ALK2; Alk8; D330013D15Rik; FOP; SKR1; Tgfb1; Tsk7L; TSRI

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UniProt ID: (Human) Q04771, (Rat) P80201, (Mouse) Q91VF1

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Entrez Gene ID: (Human) 90, (Pig) 100152307, (Rat) 79558, (Mouse) 11477

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功能
protein kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity transforming growth factor beta receptor activity, type I protein binding ATP binding activin receptor activity, type I peptide hormone binding protein homodimerization activity SMAD binding metal ion binding activin binding transforming growth factor beta binding growth factor binding nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups serine/threonine protein kinase receptor
参与通路
G1/S transition of mitotic cell cycle patterning of blood vessels in utero embryonic development gastrulation with mouth forming second mesoderm formation neural crest cell migration acute inflammatory response embryonic heart tube morphogenesis outflow tract septum morphogenesis atrioventricular valve morphogenesis mitral valve morphogenesis endocardial cushion morphogenesis endocardial cushion fusion atrial septum primum morphogenesis protein phosphorylation transforming growth factor beta receptor signaling pathway germ cell development determination of left/right symmetry negative regulation of signal transduction positive regulation of pathway-restricted SMAD protein phosphorylation peptidyl-threonine phosphorylation signal transduction by protein phosphorylation regulation of ossification positive regulation of cell migration positive regulation of bone mineralization BMP signaling pathway activin receptor signaling pathway negative regulation of activin receptor signaling pathway positive regulation of osteoblast differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter smooth muscle cell differentiation pharyngeal system development pathway-restricted SMAD protein phosphorylation ventricular septum morphogenesis cardiac muscle cell fate commitment BMP signaling pathway involved in heart development endocardial cushion cell fate commitment cellular response to glucocorticoid stimulus cellular response to BMP stimulus positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of determination of dorsal identity negative regulation of extrinsic apoptotic signaling pathway urogenital system development gastrulation mesoderm development heart development regulation of skeletal muscle tissue development transmembrane receptor protein serine/threonine kinase signaling pathway embryo development phosphorylation intracellular signal transduction
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