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Proteintech
ARL8A/ARL8B Monoclonal Antibody (2F4C3)
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ARL8A/ARL8B Antibody (68186-1-IG) in WB
Various lysates were subjected to SDS PAGE followed by western blot with 68186-1-Ig (ARL8A/ARL8B antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. The membrane was stripped and reblotted with HRP-conjugated GAPDH Monoclonal antibody (HRP-60004) as loading control.
产品信息
68186-1-IG
产品规格
种属反应
Human,
Mouse,
Rabbit,
Rat
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
2F4C3
抗原
Recombinant protein
偶联物
形式
Liquid
纯化类型
Protein A
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Immunogen sequence: MIALFNKLLD WFKALFWKEE MELTLVGLQY SGKTTFVNVI ASGQFNEDMI PTVGFNMRKI TKGNVTIKLW DIGGQPRFRS MWERYCRGVS AIVYMVDAAD QEKIEASKNE LHNLLDKPQL QGIPVLVLGN KRDLPGALDE KELIEKMNLS AIQDREICCY SISCKEKDNI DITLQWLIQH SKSRRS
靶标信息
ARL8A and ARL8B are members of the ADP-ribosylation factor-like (ARL) family of small GTPases, which play important roles in intracellular trafficking and vesicular transport. The structure of ARL8A and ARL8B consists of a conserved GTPase domain that binds to guanine nucleotides (GDP and GTP) and a C-terminal lipid modification site that allows their association with cellular membranes. They share a high degree of sequence similarity, with ARL8B being the closest homolog of ARL8A. Functionally, ARL8A and ARL8B are involved in the regulation of lysosomal positioning and trafficking. They are primarily localized to late endosomes and lysosomes, where they interact with various effector proteins to control the movement of these organelles along microtubules. ARL8A and ARL8B have been implicated in mediating lysosomal fusion events, lysosomal tubulation, and lysosome-related processes such as autophagy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ADP-ribosylation factor like GTPase 8A; ADP-ribosylation factor like GTPase 8B; ADP-ribosylation factor-like 10B; ADP-ribosylation factor-like 10C; ADP-ribosylation factor-like 8A; ADP-ribosylation factor-like 8B; ADP-ribosylation factor-like protein 10B; ADP-ribosylation factor-like protein 10C; ADP-ribosylation factor-like protein 8A; ADP-ribosylation factor-like protein 8B; Novel small G protein indispensable for equal chromosome segregation 1; Novel small G protein indispensable for equal chromosome segregation 2; small G protein indispensable for equal chromosome segregation 1; small G protein indispensable for equal chromosome segregation 2
基因别名: 1110033P22Rik; 2610313E07Rik; 3100002J04Rik; ARL10B; ARL10C; ARL8A; ARL8B; GIE1; GIE2; RGD1565940
UniProt ID: (Human) Q96BM9, (Human) Q9NVJ2, (Mouse) Q8VEH3, (Rat) Q66HA6, (Mouse) Q9CQW2
Entrez Gene ID: (Rabbit) 103351007, (Human) 127829, (Human) 55207, (Rabbit) 103352096, (Mouse) 68724, (Rat) 498234, (Rat) 500282, (Mouse) 67166
