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Invitrogen

IL-17A Recombinant Mouse Monoclonal Antibody (eBio64CAP17)

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Product Details

740128M

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

0.0625 µg/test
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1, kappa

Expression System

Expi293

Class

Recombinant Monoclonal

Type

Antibody

Clone

eBio64CAP17

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A/G

Storage buffer

PBS, pH 7.2-7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

Product Specific Information

Recombinant mouse monoclonal antibodies are produced using in vitro expression systems. Recombinant antibodies are produced using specific genes that code for the desired antibodies. These genes are cloned into an expression vector and expressed in vitro. The advantages of recombinant antibodies include better specificity and lot-to-lot consistency.

It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Target Information

Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. IL-17A is a 32 kDa long, disulfide-linked homodimer consisting of 136 amino acids that is a member of a six-species family of proteins (IL-17A-17F) and signals through the IL-17 receptor (IL-17R/CDw217). High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells, and IL-17A also enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. In particular, human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor. IL-17A regulates the activities of NF-kappa B and mitogen-activated protein kinases, stimulates the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), and enhances the production of nitric oxide (NO).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CTLA-8; Cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; il 17; IL-17; ILN; inflammatory cytokine; Interleukin; interleukin 17; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin-17; Interleukin-17A; Interleukin17A; R-IL-17-A

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Gene Aliases: CTLA-8; CTLA8; IL-17; IL-17A; IL17; IL17A; ILA17

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UniProt ID: (Human) Q16552

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Entrez Gene ID: (Human) 3605

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Function(s)
cytokine activity protein binding protein homodimerization activity protein heterodimerization activity
Process(es)
positive regulation of antimicrobial peptide production adaptive immune response immune system process apoptotic process inflammatory response immune response Notch signaling pathway cell-cell signaling cell death response to wounding gene expression positive regulation of keratinocyte proliferation keratinocyte differentiation positive regulation of interleukin-1 beta production positive regulation of interleukin-12 production positive regulation of interleukin-16 production positive regulation of interleukin-23 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production interleukin-17A-mediated signaling pathway keratinocyte proliferation innate immune response positive regulation of osteoclast differentiation positive regulation of transcription from RNA polymerase II promoter defense response to Gram-negative bacterium defense response to Gram-positive bacterium defense response to fungus positive regulation of protein kinase B signaling intestinal epithelial structure maintenance cellular response to interleukin-1 fibroblast activation regulation of primary metabolic process interleukin-17-mediated signaling pathway granulocyte migration negative regulation of inflammatory response to wounding positive regulation of cytokine production involved in inflammatory response positive regulation of bicellular tight junction assembly positive regulation of tumor necrosis factor superfamily cytokine production negative regulation of interleukin-17-mediated signaling pathway positive regulation of chemokine (C-X-C motif) ligand 1 production
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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