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PICK1 Monoclonal Antibody (L20/8), FL550
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Product Details
75-040-FL550
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
L20/8
Immunogen
Fusion protein amino acids 10-130 of rat PICK1 (accession number AAG48152) produced recombinantly in E. Coli.
Conjugate
FL550
FL550
FL550
Excitation/Emission Max
550/575 nm
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
PSD-95/DLG/ZO-1 (PDZ) domain-containing proteins play a central role in synaptic membrane protein localization. The protein interacting with protein kinase C (PICK1) is a synaptic PDZ domain protein that also contains a coiled-coil and acidic domain. Studies indicate that PICK1 functions as a targeting and transport protein and has been shown to interact with protein kinase C alpha (PKCalpha), AMPA-type glutamate receptors, and several other membrane receptors via its PDZ domain. The interaction of PICK1 with PKCalpha is highly dependent on the activation of the kinase. It appears that PICK1 directs the activated form of PKCalpha to membrane anchored GluR2. Once phosphorylated by PKCalpha, GluR2 is released from the synaptic anchor proteins. Once released, GluR2 is transported from the synaptic membrane in a PICK1-dependent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC15204; OTTHUMP00000028509; PDZ domain containing protein; PICK1; PRKCABP; protein interacting with C kinase 1; protein kinase C-alpha-binding protein; protein that interacts with C kinase 1; unnamed protein product
Gene Aliases: PICK; PRKCABP
UniProt ID: (Human) Q9NRD5, (Rat) Q9EP80
Entrez Gene ID: (Human) 9463, (Rat) 84591, (Mouse) 18693
G-protein coupled receptor binding
protein kinase C binding
receptor binding
protein binding
phospholipid binding
protein domain specific binding
identical protein binding
actin filament binding
Arp2/3 complex binding
membrane curvature sensor activity
SNAP receptor activity
cytoskeletal protein binding
receptor signaling complex scaffold activity
receptor tyrosine kinase binding
ionotropic glutamate receptor binding
G-protein coupled glutamate receptor binding
ephrin receptor binding
GTPase binding
protein transporter activity
positive regulation of receptor internalization
protein phosphorylation
protein targeting
intracellular protein transport
negative regulation of gene expression
glial cell development
regulation of Arp2/3 complex-mediated actin nucleation
negative regulation of Arp2/3 complex-mediated actin nucleation
cellular response to decreased oxygen levels
cellular response to glucose starvation
receptor clustering
regulation of insulin secretion
long term synaptic depression
membrane fusion
dendritic spine organization
dendritic spine maintenance
AMPA glutamate receptor clustering
protein insertion into plasma membrane
regulation of postsynaptic neurotransmitter receptor internalization
regulation of kainate selective glutamate receptor signaling pathway
response to phorbol 13-acetate 12-myristate
positive regulation of AMPA glutamate receptor clustering
cellular response to glycine
neuronal ion channel clustering
intracellular signal transduction
regulation of synapse structure or activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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