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WAVE1/SCAR Monoclonal Antibody (K91/36), FL650
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Product Details
75-048-FL650
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
K91/36
Immunogen
Synthetic peptide amino acids 477-498 of human Wave1/Wasp family 1(CQVIPASEPKRHPSTLPVISDAR; accession number Q92558).
Conjugate
Excitation/Emission Max
655/676 nm
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
WASP (for Wiskott-Aldrich syndrome protein) and N-WASP are downstream effectors of Cdc42 that are implicated in actin polymerization and cytoskeletal organization. The WASP family also includes VASP (vasodilator-stimulated phosphoprotein) and Mena (for mammalian enabled protein), which accumulate at focal adhesions and are also involved in the regulation of the actin cytoskeleton. The WAVE proteins are related to the WASP family proteins and are likewise involved in mediating actin reorganization downstream of the Rho family of small GTPases. The two protein homologs WAVE1 and WAVE2 specifically regulate membrane ruffling by inducing the formation of actin filament clusters in response to GTP binding and activating Rac. The WAVE proteins mediate this actin polymerization by cooperating with the Arp2/3 complex, a nucleation core, and thereby promoting the formation of actin filaments. WAVE1, which is also designated SCAR (for suppressor of cAR), is expressed primarily in the brain, while WAVE2 is widely expressed with the expression highest in peripheral blood leukocytes. WAVE3 forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Actin-binding protein WASF1; homology of dictyostelium scar 1; KIAA0269; Protein WAVE-1; Verprolin homology domain-containing protein 1; WAS protein family; WAS protein family member 1; WASP family 1; WASP family protein member 1; WASP-family protein; WAVE; Wiskott-Aldrich syndrome protein family member 1
Gene Aliases: AI195380; AI838537; KIAA0269; NEDALVS; Scar; SCAR1; WASF1; WAVE; WAVE-1; WAVE1
UniProt ID: (Human) Q92558, (Rat) Q5BJU7, (Mouse) Q8R5H6
Entrez Gene ID: (Human) 8936, (Rat) 294568, (Mouse) 83767
receptor-mediated endocytosis
mitochondrion organization
Rac protein signal transduction
actin cytoskeleton organization
actin filament polymerization
neuron projection development
positive regulation of neurotrophin TRK receptor signaling pathway
protein-containing complex assembly
lamellipodium morphogenesis
dendrite extension
modification of postsynaptic actin cytoskeleton
dendritic transport of mitochondrion
cellular response to brain-derived neurotrophic factor stimulus
positive regulation of Arp2/3 complex-mediated actin nucleation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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