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Antibodies Inc
Cav1.3 Ca2+ Channel Monoclonal Antibody (L48A/9)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
75-113
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
L48A/9
Immunogen
Synthetic peptide amino acids 859-875 (N-terminus) of rat Cav1.3 (accession number P27732).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4
Contains
0.065% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
CACNA1D is also known as PASNA, SANDD or Cav1. 3. Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: brain class D; CACNA 1D; calcium channel alpha-1 subunit; Calcium channel, L type, alpha-1 polypeptide isoform 2; Calcium channel, L type, alpha-1 polypeptide, isoform 2; CaV1.3alpha1; RBD; voltage-dependent calcium channel subunit alpha1D; Voltage-dependent L-type calcium channel subunit alpha-1D; voltage-gated calcium channel pore forming subunit CaV1.3alpha1 IVS3-IVS4 extracellular linker; Voltage-gated calcium channel subunit alpha Cav1.3
Gene Aliases: 8430418G19Rik; C79217; CACH3; CACN4; CACNA1D; CACNL1A2; Cav1.3; Cchl1a; CCHL1A2; D-LTCC
UniProt ID: (Mouse) Q99246
Entrez Gene ID: (Mouse) 12289, (Rat) 29716
voltage-gated calcium channel activity
protein binding
high voltage-gated calcium channel activity
PDZ domain binding
ankyrin binding
metal ion binding
alpha-actinin binding
voltage-gated calcium channel activity involved in cardiac muscle cell action potential
voltage-gated calcium channel activity involved SA node cell action potential
voltage-gated ion channel
calcium ion transport
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
heart development
aging
sensory perception of sound
memory
calcium-mediated signaling
positive regulation of CREB transcription factor activity
regulation of ion transmembrane transport
regulation of calcium ion transport
positive regulation of calcium ion transport
regulation of atrial cardiac muscle cell membrane repolarization
calcium ion import
calcium ion transmembrane transport
divalent metal ion transport
membrane depolarization during action potential
membrane depolarization during cardiac muscle cell action potential
membrane depolarization during SA node cell action potential
membrane repolarization during SA node cell action potential
regulation of heart rate by cardiac conduction
regulation of potassium ion transmembrane transporter activity
regulation of potassium ion transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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