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Antibodies Inc
GABA-B-R1 Monoclonal Antibody (N93A/49)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
75-183
应用
建议稀释比
已发表文章
产品规格
种属反应
Chicken,
Human,
Mouse,
Rabbit,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
N93A/49
抗原
Fusion protein amino acids 873-977 (cytoplasmic C-terminus) of rat GABABR1 (accession number Q9Z0U4) produced recombinantly in E. Coli.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
TBS, pH 7.4
内含物
0.065% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Dry ice (international)
产品详细信息
For maximum recovery of product, centrifuge the vial prior to removing the cap.
靶标信息
Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bM573K1.1.1 (gamma-aminobutyric acid (GABA) B receptor, 1a); DAAP-188P13.3; dJ271M21.1.1; dJ271M21.1.2; FLJ92613; GABA(B) receptor; GABA-B receptor 1; GABA-B-R1; Gaba-b-r1a; Gaba-b1; GABA-BR1; Gaba-br1a receptor; GABA-BR1b receptor; GABAB; GABABR1; Gababr1 receptor; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA) B receptor, 1; gamma-aminobutyric acid (GABA-B) receptor, 1; Gamma-aminobutyric acid type B receptor subunit 1; gb1; GBR1; HGB1a; OTTHUMP00000109099; OTTHUMP00000214725
基因别名: bM573K1.1; GABAB1; GABAbR1; GABBR1; GPRC3A
UniProt ID: (Mouse) Q9WV18, (Rat) Q9Z0U4
Entrez Gene ID: (Rabbit) 100353026, (Mouse) 54393, (Rat) 81657
osteoblast differentiation
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
negative regulation of adenylate cyclase activity
gamma-aminobutyric acid signaling pathway
negative regulation of cell proliferation
regulation of glutamate secretion
positive regulation of glutamate secretion
negative regulation of gamma-aminobutyric acid secretion
regulation of cAMP biosynthetic process
negative regulation of epinephrine secretion
negative regulation of dopamine secretion
negative regulation of synaptic transmission
positive regulation of growth hormone secretion
response to nicotine
response to ethanol
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