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Antibodies Inc
Pan-PTPR (Receptor-Type Tyrosine-Protein Phosphatase) Monoclonal Antibody (N165/43), FL490
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产品信息
75-194-FL490
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
N165/43
抗原
Fusion protein amino acids 1315-1607 (cytoplasmic C-terminus) of human LAR (accession number P10586) produced recombinantly in E. Coli.
偶联物
FL490
FL490
FL490
激发/发射光谱
491/515 nm
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Dry ice (international)
产品详细信息
For maximum recovery of product, centrifuge the vial prior to removing the cap.
靶标信息
Pan-PTPR refers to the collective group of Protein Tyrosine Phosphatase Receptor (PTPR) family members, which are enzymes that dephosphorylate tyrosine residues on proteins. These receptors play key roles in regulating a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Their dysregulation is often associated with various diseases, including cancer and autoimmune disorders.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: LAR; LAR-PTP2; leukocyte antigen-related (LAR) PTP receptor; Leukocyte common antigen related; Leukocyte common antigen-related protein-tyrosine phosphatase 2; leukocyte common antigen-related proten-tyrosine phosphatase 2; protein tyrosine phosphatase receptor-type F; protein tyrosine phosphatase, receptor type, D; Protein-tyrosine phosphatase delta; PTPNU-3; R-PTP-S; R-PTP-sigma; Receptor-type tyrosine-protein phosphatase delta; Receptor-type tyrosine-protein phosphatase F; Receptor-type tyrosine-protein phosphatase S; Receptor-type tyrosine-protein phosphatase sigma; tissue-specific protein tyrosine phosphatase
基因别名: 1110002J03Rik; 3000002J10Rik; AA591035; AL022616; B230219D21Rik; LAR; LARFN5C; Larptp2; LARS; PTP; PTP-NU3; PTPNU-3; PTPRD; PTPRF; PTPRS; PTPsigma; Ptpsigma.; Ptpt9; R-PTP-delta; R-PTP-S; RPTP-LAR; Rptpd; RPTPsigma
UniProt ID: (Mouse) Q64487, (Rat) Q64604, (Mouse) A2A8L5, (Mouse) B0V2N1, (Rat) Q64605
Entrez Gene ID: (Mouse) 19266, (Rat) 313278, (Rat) 360406, (Mouse) 19268, (Mouse) 19280, (Rat) 25529
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
receptor binding
protein binding
hydrolase activity
phosphatase activity
cell adhesion molecule binding
transmembrane receptor protein tyrosine phosphatase activity
insulin receptor binding
heparin binding
receptor tyrosine kinase binding
protein complex binding
chondroitin sulfate proteoglycan binding
phosphate ion binding
protein phosphatase
protein modifying enzyme
protein dephosphorylation
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
dephosphorylation
neuron differentiation
negative regulation of JAK-STAT cascade
positive regulation of dendrite morphogenesis
regulation of immune response
presynaptic membrane assembly
peptidyl-tyrosine dephosphorylation
negative regulation of cytokine-mediated signaling pathway
homophilic cell adhesion via plasma membrane adhesion molecules
nervous system development
negative regulation of cell proliferation
regulation of neuron projection development
cell migration
neuron projection regeneration
negative regulation of cell projection organization
negative regulation of epidermal growth factor receptor signaling pathway
positive regulation of apoptotic process
positive regulation of neuron apoptotic process
negative regulation of insulin receptor signaling pathway
regulation of axon regeneration
regulation of synapse structure or activity
negative regulation of neurotrophin TRK receptor signaling pathway
negative regulation of receptor binding
cell adhesion
signal transduction
spinal cord development
cerebellum development
hippocampus development
cerebral cortex development
corpus callosum development
establishment of endothelial intestinal barrier
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