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Neurexin-1-Beta Monoclonal Antibody (N170A/1), FL490

View all (8) Neurexin-1-beta antibodies

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Product Details

75-216-FL490

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

Assay-dependent
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

N170A/1

Immunogen

Synthetic peptide amino acids 47-64 of rat Neurexin-1-Beta (accession number Q63373).

Conjugate

FL490 FL490 FL490

Excitation/Emission Max

491/515 nm

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Dry ice (international)

Product Specific Information

For maximum recovery of product, centrifuge the vial prior to removing the cap.

Sequence of this protein is as follows: ASSLGAHHIH HFHGSSKH

Target Information

Neurexin-1-beta (NRXN1-beta) is a gene that encodes the beta-isoform of the neurexin-1 protein, which is a type I membrane protein that functions as a cell adhesion molecule and receptor in the nervous system. Located on chromosome 2 in humans, the neurexin-1 gene undergoes complex alternative splicing, producing multiple isoforms, including the well-studied alpha-neurexin and beta-neurexin. Neurexins, including NRXN1-beta, are primarily involved in synapse formation and function by mediating interactions between presynaptic and postsynaptic neurons. They bind to neuroligins, another family of cell adhesion molecules, thus playing a critical role in the maintenance and regulation of synaptic specificity and neurotransmitter release. Dysregulation or mutations in NRXN1-beta have been implicated in various neurological and psychiatric disorders, including autism spectrum disorders, schizophrenia, and intellectual disabilities, emphasizing the importance of this gene in brain development and function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alpha-latrotoxin receptor (calcium-dependent); neurexin 1; neurexin I; Neurexin I-alpha; Neurexin I-beta; Neurexin-1; Neurexin-1-alpha; Neurexin-1-beta; neuronal cell surface protein; non-processed neurexin I-alpha; unnamed protein product

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Gene Aliases: 1700062G21Rik; 9330127H16Rik; A230068P09Rik; Hs.22998; KIAA0578; mKIAA0578; NRXN1; Nrxn1b; PTHSL2; SCZD17

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UniProt ID: (Human) Q9ULB1, (Mouse) Q9CS84, (Rat) Q63372

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Entrez Gene ID: (Human) 9378, (Mouse) 18189, (Rat) 60391

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Function(s)
transmembrane signaling receptor activity receptor binding type 1 fibroblast growth factor receptor binding calcium channel regulator activity calcium ion binding protein binding acetylcholine receptor binding signaling receptor activity metal ion binding calcium-dependent protein binding cell adhesion molecule binding neuroligin family protein binding
Process(es)
angiogenesis cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules neuron cell-cell adhesion signal transduction chemical synaptic transmission neurotransmitter secretion axon guidance synapse assembly learning positive regulation of gene expression negative regulation of gene expression calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cerebellar granule cell differentiation neuronal signal transduction adult behavior neuron projection development positive regulation of synaptic transmission, GABAergic social behavior protein localization to synapse vocal learning positive regulation of cAMP-mediated signaling establishment of protein localization positive regulation of fibroblast growth factor receptor signaling pathway neuron projection morphogenesis neuromuscular process controlling balance negative regulation of filopodium assembly positive regulation of protein kinase B signaling positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic positive regulation of ERK1 and ERK2 cascade cellular response to calcium ion vocalization behavior protein complex assembly involved in synapse maturation positive regulation of synapse maturation synaptic vesicle clustering postsynaptic membrane assembly presynaptic membrane assembly gamma-aminobutyric acid receptor clustering NMDA glutamate receptor clustering gephyrin clustering involved in postsynaptic density assembly guanylate kinase-associated protein clustering neuroligin clustering involved in postsynaptic membrane assembly postsynaptic density protein 95 clustering receptor localization to synapse NMDA selective glutamate receptor signaling pathway AMPA selective glutamate receptor signaling pathway positive regulation of neuromuscular synaptic transmission positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of protein localization to plasma membrane positive regulation of presynaptic active zone assembly positive regulation of excitatory postsynaptic potential vesicle docking involved in exocytosis protein heterotetramerization prepulse inhibition regulation of insulin secretion involved in cellular response to glucose stimulus regulation of grooming behavior positive regulation of establishment of protein localization to plasma membrane regulation of N-methyl-D-aspartate selective glutamate receptor activity regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
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