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Neuregulin-CRD (Cysteine-Rich Domain/Type III) Monoclonal Antibody (N126B/31), FL490

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Protocols
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Neuregulin-CRD (Cysteine-Rich Domain/Type III) Monoclonal Antibody (N126B/31), FL490

Product Details

75-226-FL490

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

Assay-dependent
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

N126B/31

Immunogen

Fusion protein amino acids 1-75 (membrane-associated N-terminus) of human Neuregulin-1 (accession number Q96IB3) produced recombinantly in E. Coli.
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Conjugate

FL490 FL490 FL490

Excitation/Emission Max

491/515 nm

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Dry ice (international)

Product Specific Information

For maximum recovery of product, centrifuge the vial prior to removing the cap.

Target Information

Neuregulin-CRD refers to the cysteine-rich domain (CRD) of neuregulins, a family of signaling proteins involved in various cellular processes, including growth, differentiation, and development. The cysteine-rich domain is critical for the interaction of neuregulins with their receptors, such as the ErbB family of receptor tyrosine kinases, facilitating the activation of downstream signaling pathways. This domain plays a vital role in the proper functioning of neuregulins in the nervous system, heart, and other tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: acetylcholine receptor-inducing activity; glial growth factor 2; heregulin, alpha (45kD, ERBB2 p185-activator); neu differentiation factor; neuregulin 1 type III beta 3; Pro-neuregulin-1, membrane-bound isoform; Pro-NRG1; sensory and motor neuron derived factor

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Gene Aliases: ARIA; GGF; GGF2; HGL; HRG; HRG1; HRGA; MST131; MSTP131; NDF; NRG1; NRG1-IT2; SMDF

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UniProt ID: (Human) Q02297

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Entrez Gene ID: (Human) 3084, (Rat) 112400

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Function(s)
transcription cofactor activity protein tyrosine kinase activity Ras guanyl-nucleotide exchange factor activity cytokine activity ErbB-2 class receptor binding integrin binding growth factor activity transmembrane receptor protein tyrosine kinase activator activity receptor tyrosine kinase binding ErbB-3 class receptor binding chemorepellent activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity receptor binding protein tyrosine kinase activator activity growth factor
Process(es)
MAPK cascade activation of MAPK activity cell morphogenesis startle response cardiac conduction system development ventricular trabecula myocardium morphogenesis cell communication activation of transmembrane receptor protein tyrosine kinase activity nervous system development synapse assembly peripheral nervous system development locomotory behavior regulation of blood pressure positive regulation of cell proliferation embryo development neural crest cell development regulation of phosphatidylinositol 3-kinase signaling positive regulation of phosphatidylinositol 3-kinase signaling glucose transport peptidyl-tyrosine phosphorylation glial cell fate commitment chemorepulsion involved in interneuron migration from the subpallium to the cortex mammary gland development positive regulation of myelination activation of protein kinase B activity intracellular signal transduction ERBB signaling pathway ERBB2 signaling pathway wound healing negative regulation of protein catabolic process myelination regulation of protein homodimerization activity regulation of protein heterodimerization activity positive regulation of GTPase activity neurotransmitter receptor metabolic process positive regulation of axon extension negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of Ras protein signal transduction phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling neuron fate commitment oligodendrocyte differentiation positive regulation of peptidyl-tyrosine phosphorylation negative regulation of secretion positive regulation of striated muscle cell differentiation positive regulation of protein kinase B signaling cardiac muscle cell differentiation cardiac muscle cell myoblast differentiation endocardial cell differentiation positive regulation of dendritic spine development positive regulation of calcineurin-NFAT signaling cascade positive regulation of protein targeting to mitochondrion positive regulation of protein localization to cell surface regulation of cell motility positive regulation of cardiac muscle cell differentiation negative regulation of neuron migration transmembrane receptor protein tyrosine kinase signaling pathway heart development muscle organ development cell proliferation glial cell differentiation negative regulation of cardiac muscle cell apoptotic process cell migration cell differentiation positive regulation of cell growth cellular protein complex disassembly regulation of cell differentiation positive regulation of cell adhesion positive regulation of protein kinase activity animal organ development ventricular cardiac muscle cell differentiation positive regulation of cardiac muscle cell proliferation positive regulation of protein tyrosine kinase activity negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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