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TrpV1 Monoclonal Antibody (N221/17)
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Product Details
75-254
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N221/17
Immunogen
Fusion protein amino acids 1-160 (cytoplasmic N-terminus) of rat TrpV1 (accession number O35433) produced recombinantly in E. Coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4
Contains
0.065% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) is a receptor for capsaicin, the main pungent ingredient in hot chili peppers, and elicits a sensation of burning pain by selectively activating sensory neurons. TRPV1 is a non-selective cation channel that is structurally related to members of the TRP family of ion channels such as TRPC3 and TRPC6. TRPV1 is permeable to calcium, magnesium, and monovalent cations of sodium and potassium. Structurally, TRPV1 contains 6 trans-membrane domains, a P-loop membrane domain and 3 ankyrin repeat domains. TRPV1 is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. TRPV1 seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. The expression of TRPV1 appears to be limited to neurons within the sensory ganglia. Four transcript variants encoding TRPV1 with variations in th 5' UTR sequence have been described. Diseases associated with TRPV1 include Irritable Bowel Syndrome (IBS) and Bladder Disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Capsaicin receptor; cation channel; DKFZp434K0220; ion channel; Osm-9-like TRP channel 1; OTRPC1; Transient receptor potential cation channel subfamily V member 1; transient receptor potential cation channel V1; transient receptor potential vanilloid 1 supraoptic nucleus; transient receptor potential vanilloid 1a; transient receptor potential vanilloid 1b; TrpV1; truncated capsaicin receptor protein; Vanilloid receptor; Vanilloid receptor 1; vanilloid receptor subtype 1; vanilloid receptor type 1 like protein 1; Vanilloid receptor type 1-like; vanilloid type 1 receptor; VR1; VR1 receptor
Gene Aliases: OTRPC1; TRPV1; TRPV1_SON; TRPV1alpha; TRPV1beta; VR-1; VR.5'sv; VR1; Vr1l; Vr1l1
UniProt ID: (Human) Q8NER1, (Rat) O35433, (Mouse) Q704Y3
Entrez Gene ID: (Human) 7442, (Rat) 83810, (Mouse) 193034
nucleotide binding
transmembrane signaling receptor activity
ion channel activity
extracellular ligand-gated ion channel activity
excitatory extracellular ligand-gated ion channel activity
voltage-gated calcium channel activity
calcium channel activity
protein binding
calmodulin binding
ATP binding
calcium-release channel activity
phosphatidylinositol binding
metal ion binding
phosphoprotein binding
temperature-gated ion channel activity
cation channel activity
cation transmembrane transporter activity
ligand-gated ion channel activity
chloride channel regulator activity
identical protein binding
ion channel
negative regulation of transcription from RNA polymerase II promoter
temperature homeostasis
fever generation
diet induced thermogenesis
peptide secretion
lipid metabolic process
ion transport
calcium ion transport
cell surface receptor signaling pathway
chemosensory behavior
response to pH
response to heat
urinary bladder smooth muscle contraction
sensory perception of pain
calcium-mediated signaling
ion transmembrane transport
cellular response to heat
response to pain
behavioral response to pain
sensory perception of taste
sensory perception of mechanical stimulus
thermoception
detection of temperature stimulus involved in thermoception
detection of temperature stimulus involved in sensory perception of pain
detection of chemical stimulus involved in sensory perception of pain
protein homotetramerization
transmembrane transport
excitatory postsynaptic potential
smooth muscle contraction involved in micturition
calcium ion transmembrane transport
cellular response to alkaloid
cellular response to ATP
cellular response to acidic pH
calcium ion import across plasma membrane
response to capsazepine
calcium ion import into cytosol
microglial cell activation
inflammatory response
signal transduction
positive regulation of cytosolic calcium ion concentration
response to organonitrogen compound
glutamate secretion
positive regulation of apoptotic process
response to peptide hormone
positive regulation of nitric oxide biosynthetic process
positive regulation of gastric acid secretion
cellular response to cytokine stimulus
cellular response to tumor necrosis factor
cellular response to growth factor stimulus
cellular response to temperature stimulus
negative regulation of establishment of blood-brain barrier
cellular response to nerve growth factor stimulus
transport
cation transport
catagen
cation transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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