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Chapsyn-110 MAGUK Monoclonal Antibody (N18/28)
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Product Details
75-284
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chicken,
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
N18/28
Immunogen
Fusion protein amino acids 1-852 (full-length) of rat Chapsyn-110 (accession number Q63622) produced recombinantly in E. Coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4
Contains
0.065% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
PSD-93, also known as chapsyn-110, is one of a family of plasma membrane-associated proteins found in synaptic junctions. PSD-93 is unique among family members in its expression in Purkinje neuron cell bodies and dendrites. PSD-93 has three ~90 amino acid repeats called PDZ domains, a single interior SH3 domain, and a carboxyl-terminal guanylate kinase homology (GuK) domain that is enzymatically inactive. It is hypothesized that PDZ-domain interactions play a role in receptor and channel clustering which contributes to neuronal plasticiyt. PSD-93 is believed to participate in the clustering of certain proteins, including NMDA receptors and shaker-type potassium channels at the synaptic membrane. There are two principal modes of interaction between PSD-93 and other proteins. NMDA receptors and shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif may interact with PSD-93 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with PSD-93 in vitro through a pseudo-homotypic PDZ-PDZ interaction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Channel-associated protein of synapse-110; channel-associated protein of synapses, 110kDa; Chapsyn-1; Chapsyn-110; discs large homolog 2; discs, large homolog 2, chapsyn-110; Disks large homolog 2; Postsynaptic density protein PSD-93; protein phosphatase 1, regulatory subunit 58; synaptic density protein PSD-93; unnamed protein product
Gene Aliases: A330103J02Rik; B230218P12Rik; B330007M19Rik; chapsyn-110; DLG2; Dlgh2; Gm1197; PPP1R58; PSD-93; PSD93
UniProt ID: (Human) Q15700, (Mouse) Q91XM9, (Rat) Q63622
Entrez Gene ID: (Human) 1740, (Chicken) 419024, (Mouse) 23859, (Rat) 64053
chemical synaptic transmission
nervous system development
protein localization to synapse
cellular response to potassium ion
receptor clustering
establishment or maintenance of epithelial cell apical/basal polarity
GMP metabolic process
GDP metabolic process
receptor localization to synapse
cell-cell adhesion
regulation of postsynaptic membrane neurotransmitter receptor levels
anterograde axonal protein transport
retrograde axonal protein transport
negative regulation of phosphatase activity
sensory perception of pain
neuronal ion channel clustering
nucleotide phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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