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Antibodies Inc
GABA-A-R-Alpha5 Monoclonal Antibody (N415/24)
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GABA-A-R-Alpha5 Antibody (75-401) in ICC/IF
Immunolabelling showing alpha-1-/alpha-5-containing GABAA receptors demonstrated synaptic localizations in a primary hippocampal neuronal culture. Distributions of alpha-1 and alpha-5 (Product # 75-401, 1:1000) subunits (A,B) were co-stained with the inhibitory presynaptic marker protein vGat (C). (D) The alpha-1 subunit was mostly synaptically localized, opposing vGat, whereas alpha-5 was distributed at bo... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
75-401
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
N415/24
抗原
Fusion protein amino acids 368-419 (last cytoplasmic domain before extracellular C-terminus) of human GABA-A-R-Alpha5 (accession number P31644) produced recombinantly in E. Coli.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
TBS, pH 7.4
内含物
0.065% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Dry ice (international)
产品详细信息
For maximum recovery of product, centrifuge the vial prior to removing the cap.
靶标信息
GABRA5 is a part of GABA, a major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GABA(A) receptor; GABA(A) receptor subunit alpha-5; GABA-A receptor alpha-5 subunit; GABAA receptor alpha5 subunit; GABAAR subunit alpha-5; gamma-aminobutyric acid; gamma-aminobutyric acid A receptor, alpha 5; gamma-aminobutyric acid (GABA) A receptor, alpha 5; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 5; gamma-aminobutyric acid A receptor, alpha 5; Gamma-aminobutyric acid receptor subunit alpha-5; gamma-aminobutyric acid type A receptor alpha5 subunit; ligand-gated ion channel subunit; unnamed protein product
基因别名: A230018I05Rik; DEE79; EIEE79; Gabra-5; GABRA5
UniProt ID: (Human) P31644, (Rat) P19969, (Mouse) Q8BHJ7
Entrez Gene ID: (Human) 2558, (Rat) 29707, (Mouse) 110886
transmembrane signaling receptor activity
GABA-A receptor activity
ion channel activity
extracellular ligand-gated ion channel activity
chloride channel activity
benzodiazepine receptor activity
GABA-gated chloride ion channel activity
signaling receptor activity
GABA receptor binding
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
protein binding
ligand-gated ion channel
behavioral fear response
ion transport
chloride transport
signal transduction
gamma-aminobutyric acid signaling pathway
chemical synaptic transmission
associative learning
ion transmembrane transport
neuron development
synaptic transmission, GABAergic
regulation of postsynaptic membrane potential
inner ear receptor cell development
innervation
cochlea development
regulation of presynaptic membrane potential
chloride transmembrane transport
inhibitory synapse assembly
brain development
sensory perception of sound
regulation of neuron apoptotic process
negative regulation of neuron apoptotic process
positive regulation of defense response to virus by host
transport
mitophagy in response to mitochondrial depolarization
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