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Pan-Nav1 Sodium Channel Monoclonal Antibody (N419/40)

View all (17) Sodium Channel Pan antibodies

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Datasheet
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Pan-Nav1 Sodium Channel Monoclonal Antibody (N419/40)

Product Details

75-405

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Frozen) (IHC (F))

Assay-dependent
-

Immunocytochemistry (ICC/IF)

1:250
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

N419/40

Immunogen

Synthetic peptide amino acids 1501-1518 of human Nav1.1 (accession number P35498).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

TBS, pH 7.4

Contains

0.065% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Dry ice (international)

Product Specific Information

For maximum recovery of product, centrifuge the vial prior to removing the cap.

Sequence of this protein is as follows: TEEQKKYYNA MKKLGSKK

Target Information

Voltage-gated sodium channels (NaV) are essential for the generation of action potentials and for cell excitability. NaV channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine NaV alpha subunits have been cloned and named NaV1.1-NaV1.9. The NaV channels are classified into two groups according to their sensitivity to tetrodotoxin (TTX): TTX-sensitive (NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.6 and NaV1.7) and TTX-resistant (NaV1.5, NaV1.8 and NaV1.9). Mammalian sodium channels are heterotrimers, composed of a central, pore-forming alpha subunit and two auxiliary beta subunits. The expression of the alpha subunit isoform is developmentally regulated and tissue specific. Sodium channels in the adult central nervous system and heart contain beta 1 through beta 4 subunits, whereas sodium channels in adult skeletal muscle have only the beta 1 subunit.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 3-Feb; alternative product; ataxia 3; brain III voltage-gated sodium channel; cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit; CTC-264K15.6; HBSC II; hH1; hNa6/Scn8a voltage-gated sodium channel; hNaN; hNE-Na; mH1; Mu-1; Na+ channel; NaCh6; NaN; Neuroendocrine sodium channel; Peripheral nerve protein type 4; Peripheral nerve sodium channel 3; Peripheral nerve sodium channel 5; Peripheral sodium channel 1; PN1; PN3; PN4; PN5; RIIA sodium channel protein; Sensory neuron sodium channel; Sensory neuron sodium channel 2; skeletal muscle sodium channel alpha subunit; skeletal muscle voltage-dependent sodium channel type IV alpha subunit; SkM1; sodium channel 25; Sodium channel 6; sodium channel alpha-subunit; Sodium channel protein brain I subunit alpha; Sodium channel protein brain II subunit alpha; Sodium channel protein brain III subunit alpha; Sodium channel protein cardiac muscle subunit alpha; Sodium channel protein skeletal muscle subunit alpha; Sodium channel protein type 1 subunit alpha; Sodium channel protein type 10 subunit alpha; Sodium channel protein type 11 subunit alpha; Sodium channel protein type 2 subunit alpha; Sodium channel protein type 3 subunit alpha; Sodium channel protein type 4 subunit alpha; Sodium channel protein type 5 subunit alpha; Sodium channel protein type 8 subunit alpha; Sodium channel protein type 9 subunit alpha; Sodium channel protein type I subunit alpha; Sodium channel protein type II subunit alpha; Sodium channel protein type III subunit alpha; Sodium channel protein type IV subunit alpha; Sodium channel protein type IX subunit alpha; Sodium channel protein type V subunit alpha; Sodium channel protein type VIII subunit alpha; Sodium channel protein type X subunit alpha; Sodium channel protein type XI subunit alpha; sodium channel protein, brain I alpha subunit; sodium channel protein, brain I subunit alpha; sodium channel protein, brain II subunit alpha; sodium channel protein, brain III subunit alpha; sodium channel protein, brain type 2 alpha subunit; sodium channel type X alpha polypeptide; sodium channel voltage gated type 1 alpha subunit; sodium channel voltage-gated type 11 alpha polypeptide; sodium channel voltage-gated type 4 alpha polypeptide; sodium channel voltage-gated type I alpha polypeptide; sodium channel voltage-gated type II alpha polypeptide; Sodium channel voltage-gated type IV alpha polypeptide; sodium channel voltage-gated type V alpha polypeptide; sodium channel voltage-gated type VIII alpha polypeptide; sodium channel voltage-gated type X alpha polypeptide; sodium channel voltage-gated type XI alpha polypeptide; sodium channel, voltage gated, type I alpha subunit; sodium channel, voltage gated, type II alpha subunit; sodium channel, voltage gated, type III alpha subunit; sodium channel, voltage gated, type IV alpha subunit; sodium channel, voltage gated, type IX alpha subunit; sodium channel, voltage gated, type V alpha subunit; sodium channel, voltage gated, type VIII alpha subunit; sodium channel, voltage gated, type VIII, alpha subunit; sodium channel, voltage gated, type X alpha subunit; sodium channel, voltage gated, type XI alpha subunit; sodium channel, voltage-gated, type 1, alpha polypeptide; sodium channel, voltage-gated, type 10, alpha polypeptide; sodium channel, voltage-gated, type 11, alpha polypeptide; sodium channel, voltage-gated, type 2, alpha 1 polypeptide; sodium channel, voltage-gated, type 2, alpha 1 subunit; sodium channel, voltage-gated, type 3, alpha subunit; sodium channel, voltage-gated, type 4, alpha polypeptide; sodium channel, voltage-gated, type 4, alpha subunit; sodium channel, voltage-gated, type 5, alpha subunit; sodium channel, voltage-gated, type 8, alpha polypeptide; sodium channel, voltage-gated, type 8, alpha subunit; sodium channel, voltage-gated, type 9, alpha polypeptide; sodium channel, voltage-gated, type I, alpha polypeptide; sodium channel, voltage-gated, type I, alpha subunit; sodium channel, voltage-gated, type II, alpha 1; sodium channel, voltage-gated, type II, alpha 1 polypeptide; sodium channel, voltage-gated, type II, alpha 2 polypeptide; sodium channel, voltage-gated, type II, alpha polypeptide 1; sodium channel, voltage-gated, type II, alpha subunit; sodium channel, voltage-gated, type III, alpha polypeptide; sodium channel, voltage-gated, type IV, alpha polypeptide; sodium channel, voltage-gated, type IV, alpha subunit; sodium channel, voltage-gated, type IX, alpha polypeptide; sodium channel, voltage-gated, type IX, alpha subunit; sodium channel, voltage-gated, type V, alpha polypeptide; sodium channel, voltage-gated, type V, alpha subunit; sodium channel, voltage-gated, type VIII, alpha polypeptide; sodium channel, voltage-gated, type X, alpha polypeptide; sodium channel, voltage-gated, type X, alpha subunit; sodium channel, voltage-gated, type XI, alpha polypeptide; sodium channel, voltage-gated, type XI, alpha subunit; sodium channel, voltage-gated, type XII, alpha polypeptide; sodium channel, voltage-gated, type11, alpha polypeptide; SP-19; voltage gated sodium channel; voltage-gated sodium channel alpha subunit Nav1.7; voltage-gated sodium channel Nav1.5c; voltage-gated sodium channel NAV1.9b; voltage-gated sodium channel subtype II; Voltage-gated sodium channel subtype III; Voltage-gated sodium channel subunit alpha Nav1.1; Voltage-gated sodium channel subunit alpha Nav1.2; Voltage-gated sodium channel subunit alpha Nav1.3; Voltage-gated sodium channel subunit alpha Nav1.4; Voltage-gated sodium channel subunit alpha Nav1.5; Voltage-gated sodium channel subunit alpha Nav1.6; Voltage-gated sodium channel subunit alpha Nav1.7; Voltage-gated sodium channel subunit alpha Nav1.8; Voltage-gated sodium channel subunit alpha Nav1.9; voltage-gated sodium channel type II alpha subunit; voltage-gated sodium channel type VIII alpha protein

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Gene Aliases: 6430408L10; A230052E19Rik; AI853486; B230332M13; BFIC3; BFIS3; BFNIS; C630029C19Rik; CDCD2; CERIII; CIAT; CMD1E; CMPD2; CMS16; dmu; EIEE11; EIEE13; EIEE6; ETHA; FEB3; FEB3A; FEB3B; FEPS2; FEPS3; FHM3; GEFSP2; GEFSP7; Gm1000; HB1; HB2; HBA; HBBD; HBSCI; HBSCII; HH1; HOKPP2; hPN3; HSAN2D; HSAN7; HYKPP; HYPP; ICCD; IVF; KIAA1356; Kiaa4197; LQT3; MED; mH1; mH2; microI; mKIAA4197; mnd-2; mnd2; Na(v)1.2; Na(V)1.4; Na(V)1.8; NAC1; NAC1A; NAC2; NAC3; NaCh6; NachII; NaN; NaT; Nav1.1; Nav1.2; Nav1.3; Nav1.4; Nav1.5; Nav1.5c; Nav1.6; Nav1.7; Nav1.8; NAV1.9; Nbna1; NCHVS; NE-NA; NENA; nmf2; nmf335; nmf58; NSS2; nur14; PFHB1; PN1; PN3; PN4; PN5; RII/RIIA; RNSCPIIR; SCAL; SCIII; SCN; SCN1; SCN10A; SCN11A; SCN12A; SCN1A; SCN2A; SCN2A1; SCN2A2; SCN3A; SCN4A; SCN5A; SCN8A; SCN9A; ScpII; seal; SFNP; SkM1; SkM2; SMEI; SNS; SNS-2; SNS2; SSS1; VF1

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UniProt ID: (Human) Q9Y5Y9, (Human) Q9UI33, (Human) P35498, (Human) Q99250, (Human) Q9NY46, (Human) P35499, (Human) E9PEK2, (Human) Q9UQD0, (Human) Q15858, (Rat) Q62968, (Mouse) Q6QIY3, (Rat) O88457, (Mouse) Q9R053, (Rat) P04774, (Mouse) A2APX8, (Rat) P04775, (Mouse) B1AWN6, (Mouse) A2ASI5, (Rat) P08104, (Mouse) Q9ER60, (Rat) P15390, (Rat) P15389, (Mouse) Q9JJV9, (Mouse) Q9WTU3, (Rat) O88420, (Mouse) Q62205, (Rat) O08562

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Entrez Gene ID: (Human) 6336, (Human) 11280, (Human) 6323, (Human) 6326, (Human) 6328, (Human) 6329, (Human) 6331, (Human) 6334, (Human) 6335, (Rat) 29571, (Mouse) 20264, (Rat) 29701, (Mouse) 24046, (Rat) 81574, (Mouse) 20265, (Rat) 24766, (Mouse) 110876, (Mouse) 20269, (Rat) 497770, (Mouse) 110880, (Rat) 25722, (Rat) 25665, (Mouse) 20271, (Mouse) 20273, (Rat) 29710, (Mouse) 20274, (Rat) 78956

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Function(s)
voltage-gated sodium channel activity ion channel binding sodium ion binding calmodulin binding protein binding fibroblast growth factor binding enzyme binding protein kinase binding protein domain specific binding ankyrin binding ubiquitin protein ligase binding nitric-oxide synthase binding voltage-gated sodium channel activity involved in cardiac muscle cell action potential voltage-gated sodium channel activity involved in AV node cell action potential voltage-gated sodium channel activity involved in bundle of His cell action potential voltage-gated sodium channel activity involved in Purkinje myocyte action potential voltage-gated sodium channel activity involved in SA node cell action potential scaffold protein binding ATP binding ion channel activity voltage-gated ion channel activity sodium channel activity leucine zipper domain binding nucleotide binding voltage-gated ion channel
Process(es)
regulation of heart rate sensory perception neuronal action potential sensory perception of pain regulation of ion transmembrane transport sodium ion transmembrane transport odontogenesis of dentin-containing tooth regulation of cardiac muscle contraction regulation of postsynaptic membrane potential regulation of atrial cardiac muscle cell membrane depolarization membrane depolarization during action potential AV node cell action potential bundle of His cell action potential sodium ion transport response to drug regulation of sensory perception of pain positive regulation of defense response to virus by host adult walking behavior neuronal action potential propagation neuromuscular process controlling posture xenophagy intrinsic apoptotic signaling pathway in response to osmotic stress myelination neuron apoptotic process nervous system development response to wounding response to pyrethroid cellular response to antibiotic potassium ion transport muscle contraction choline transport cardiac ventricle development brainstem development positive regulation of sodium ion transport response to denervation involved in regulation of muscle adaptation telencephalon development cerebellum development positive regulation of action potential positive regulation of epithelial cell proliferation membrane depolarization cardiac muscle contraction regulation of ventricular cardiac muscle cell membrane repolarization regulation of atrial cardiac muscle cell membrane repolarization regulation of ventricular cardiac muscle cell membrane depolarization cardiac conduction cellular response to calcium ion cardiac muscle cell action potential involved in contraction regulation of cardiac muscle cell contraction ventricular cardiac muscle cell action potential membrane depolarization during cardiac muscle cell action potential SA node cell action potential membrane depolarization during AV node cell action potential membrane depolarization during SA node cell action potential membrane depolarization during Purkinje myocyte cell action potential membrane depolarization during bundle of His cell action potential AV node cell to bundle of His cell communication regulation of heart rate by cardiac conduction regulation of sodium ion transmembrane transport peripheral nervous system development inflammatory response response to toxic substance post-embryonic development behavioral response to pain bundle of His cell to Purkinje myocyte communication transport ion transport transmembrane transport action potential regulation of membrane potential cation transport positive regulation of heart rate response to organic cyclic compound SA node cell to atrial cardiac muscle cell communication muscle organ development sensory perception of sound locomotory behavior adult locomotory behavior neuromuscular process rhythmic excitation
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