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Navbeta1 Na+ Channel Monoclonal Antibody (N405/74)
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Product Details
75-425
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
N405/74
Immunogen
Fusion protein amino acids 14-160 (extracellular N-terminus) of rat Navbeta1 (accession number Q00954) produced recombinantly in E. Coli.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4
Contains
0.065% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. SCN1B encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: sodium channel subunit beta-1; sodium channel, voltage-gated, type 1, beta polypeptide; sodium channel, voltage-gated, type I, beta polypeptide; sodium channel, voltage-gated, type I, beta subunit; unnamed protein product
UniProt ID: (Mouse) P97952, (Rat) Q00954
Entrez Gene ID: (Mouse) 20266, (Rat) 29686
regulation of sodium ion transport
sodium ion transport
axon guidance
positive regulation of sodium ion transport
positive regulation of neuron projection development
neuronal action potential propagation
corticospinal neuron axon guidance
sodium ion transmembrane transport
locomotion
response to pyrethroid
membrane depolarization
cardiac muscle contraction
regulation of ventricular cardiac muscle cell membrane repolarization
regulation of atrial cardiac muscle cell membrane depolarization
cardiac conduction
cardiac muscle cell action potential involved in contraction
membrane depolarization during action potential
membrane depolarization during cardiac muscle cell action potential
membrane depolarization during Purkinje myocyte cell action potential
regulation of heart rate by cardiac conduction
regulation of sodium ion transmembrane transport
regulation of voltage-gated sodium channel activity
positive regulation of voltage-gated sodium channel activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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