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7TM Antibodies
FPR2, Formylpeptide Receptor 2 Polyclonal Antibody
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FPR2, Formylpeptide Receptor 2 Antibody (7TM0223N-IC) in IHC (P)
Immunohistochemical identification of the Formylpeptide Receptor 2 in striatum. Sections were dewaxed, microwaved in citric acid, and incubated with anti-FPR2 (Formylpeptide Receptor 2) antibody (7TM0223N-IC) at a dilution of 1:100. Sections were then sequentially treated with biotinylated anti-rabbit IgG and avidin-biotin solution. Color was developed by incubation in 3-amino-9-ethylcarbazole (AEC), and se... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
7TM0223N-IC
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to distal end of carboxy-terminal tail of human FPR2.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
Dulbecco's PBS, pH 7.4
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Formyl peptide receptor 2 (FPR2) is a low affinity receptor for N-formyl-methionyl peptides. Binding of FMLP to FPR2 causes activation of neutrophils. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FMLP-R-I; FMLP-related receptor I; fMLPR1; formyl peptide receptor-like 1; FPR-like 1; Fpr-rs1; Fprl-1; lipoxin A4 receptor (formyl peptide receptor related); Lipoxin receptor; LXA4 receptor; RFP; unnamed protein product
基因别名: ALX; ALXR; FMLP-R-II; FMLPX; FPR2A; FPRH1; FPRH2; FPRL1; HM63; LXA4R
UniProt ID: (Human) P25090
Entrez Gene ID: (Human) 2358
microglial cell activation
complement receptor mediated signaling pathway
immune response-regulating cell surface receptor signaling pathway
receptor-mediated endocytosis
chemotaxis
inflammatory response
cell communication
cell adhesion
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
calcium-mediated signaling
signaling
positive regulation of superoxide anion generation
defense response to bacterium
positive regulation of innate immune response
astrocyte activation
negative regulation of inflammatory response
positive regulation of phagocytosis
positive chemotaxis
positive regulation of protein kinase B signaling
positive regulation of ERK1 and ERK2 cascade
positive regulation of monocyte chemotaxis
cellular response to beta-amyloid
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