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Proteintech
PICK1 Recombinant Rabbit Monoclonal Antibody (230185B8)
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Product Details
82919-1-RR
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
230185B8
Immunogen
PICK1 fusion protein Ag1443
Conjugate
Form
Liquid
Concentration
0.8 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MFADLDYDIE EDKLGIPTVP GKVTLQKDAQ NLIGISIGGG AQYCPCLYIV QVFDNTPAAL DGTVAAGDEI TGVNGRSIKG KTKVEVAKMI QEVKGEVTIH YNKLQADPKQ GMSLDIVLKK VKHRLVENMS SGTADALGLS RAILCNDGLV KRLEELERTA ELYKGMTEHT KNLLRAFYEL SQTHRAFGDV FSVIGVREPQ PAASEAFVKF ADAHRSIEKF GIRLLKTIKP MLTDLNTYLN KAIPDTRLTI KKYLDVKFEY LSYCLKVKEM DDEEYSCIAL GEPLYRVSTG NYEYRLILRC RQEARARFSQ MRKDVLEKME LLDQKHVQDI VFQLQRLVST MSKYYNDCYA VLRDADVFPI EVDLAHTTLA YGLNQEEFTD GEEEEEEEDT AAGEPSRDTR GAAGPLDKGG SWCDS
Target Information
PSD-95/DLG/ZO-1 (PDZ) domain-containing proteins play a central role in synaptic membrane protein localization. The protein interacting with protein kinase C (PICK1) is a synaptic PDZ domain protein that also contains a coiled-coil and acidic domain. Studies indicate that PICK1 functions as a targeting and transport protein and has been shown to interact with protein kinase C alpha (PKCalpha), AMPA-type glutamate receptors, and several other membrane receptors via its PDZ domain. The interaction of PICK1 with PKCalpha is highly dependent on the activation of the kinase. It appears that PICK1 directs the activated form of PKCalpha to membrane anchored GluR2. Once phosphorylated by PKCalpha, GluR2 is released from the synaptic anchor proteins. Once released, GluR2 is transported from the synaptic membrane in a PICK1-dependent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC15204; OTTHUMP00000028509; PRKCA-binding protein; Protein interacting with C kinase 1; protein kinase C, alpha binding protein; Protein kinase C-alpha-binding protein; protein that interacts with C kinase 1
Gene Aliases: PICK; PICK1; PRKCABP
UniProt ID: (Human) Q9NRD5, (Rat) Q9EP80
Entrez Gene ID: (Pig) 100158107, (Human) 9463, (Mouse) 18693, (Rat) 84591
G-protein coupled receptor binding
protein kinase C binding
receptor binding
protein binding
protein C-terminus binding
ATPase activity
enzyme binding
protein domain specific binding
identical protein binding
metal ion binding
actin filament binding
Arp2/3 complex binding
actin binding
kinase activity
receptor tyrosine kinase binding
G-protein coupled glutamate receptor binding
ephrin receptor binding
GTPase binding
vesicle coat protein
positive regulation of receptor internalization
protein phosphorylation
retrograde vesicle-mediated transport, Golgi to ER
protein kinase C-activating G-protein coupled receptor signaling pathway
monoamine transport
glial cell development
regulation of Arp2/3 complex-mediated actin nucleation
negative regulation of Arp2/3 complex-mediated actin nucleation
cellular response to decreased oxygen levels
cellular response to glucose starvation
DNA methylation involved in embryo development
DNA methylation involved in gamete generation
receptor clustering
neuronal ion channel clustering
long term synaptic depression
dendritic spine organization
dendritic spine maintenance
protein targeting
multicellular organism development
negative regulation of gene expression
intracellular signal transduction
regulation of synaptic plasticity
regulation of synapse structure or activity
protein homooligomerization
negative regulation of cell death
dopamine transport
phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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