NeoBiotechnologies

CD63 (Late Endosomes Marker) Monoclonal Antibody (MX-49.129.5), PE

Name: CD63 (Late Endosomes Marker) Monoclonal Antibody (MX-49.129.5), PE
Brand: NeoBiotechnologies
SKU: 967-MSM2-PE-100T

查看其他95个CD63抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (2)

CD63 (Late Endosomes Marker) Antibody in Flow Cytometry (Flow)

图: 1 / 2

CD63 (Late Endosomes Marker) Antibody (967-MSM2-PE-100T) in Flow

Flow Cytometric staining of Mouse CD63 on NIH/3T3 cells. Black: cells alone; Green: Isotype Control; Red: PE-labeled CD63 Monoclonal Antibody (MX-49.129.5).

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Immunogen image

Immunogen Image CD63 (Late Endosomes Marker) Monoclonal Antibody (MX-49.129.5), PE

产品信息

967-MSM2-PE-100T

应用

建议稀释比

已发表文章

免疫细胞化学 (ICC/IF)

1:50-1:100

流式细胞分析 (Flow)

5 µL/10^6 cells

产品规格

种属反应

Human, Mouse

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

MX-49.129.5

抗原

Full length CD63 of human origin

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偶联物

PE PE PE

激发/发射光谱

565/576 nm 查看光谱

形式

Liquid

浓度

100 µg/mL

纯化类型

Protein A/G

保存液

PBS, pH 7.4, with 0.05% BSA

内含物

0.05% sodium azide

保存条件

4°C, store in dark, DO NOT FREEZE!

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

CD63, also known as LAMP-3, is a glycoprotein belonging to the tetraspanin family, primarily located in late endosomes, lysosomes, and secretory vesicles across various cell types. It is expressed intracellularly in resting platelets and basophils, but upon activation, CD63 translocates to the plasma membrane, making it a widely used marker for basophil activation. Unlike basophils, mast cells can expose CD63 without activation. CD63 is expressed on activated platelets, monocytes, macrophages, and granulocytes, as well as endothelial cells, fibroblasts, and smooth muscle cells. It interacts with integrins (such as VLA-3 and VLA-6) and TIMP-1, playing roles in mediating allergic responses, phagocytosis, and cell migration. Additionally, CD63 is involved in the regulation of H/K-ATPase trafficking and ROMK1 channels, and serves as a T-cell costimulation molecule. CD63 expression can be used to predict prognosis in early-stage carcinomas and is identical to the melanoma-associated antigen ME491 and the platelet antigen PTLGP40. Diseases associated with CD63 dysfunction include melanoma and Hermansky-Pudlak Syndrome, highlighting its significance in both immune responses and disease processes.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: CD 63; CD63; CD63 antigen; CD63 antigen (melanoma 1 antigen); Granulophysin; LAMP-3; Limp1; Lysosomal-associated membrane protein 3; Lysosome integral membrane protein 1; lysosome-associated membrane glycoprotein 3; melanoma 1 antigen; Melanoma-associated antigen ME491; melanoma-associated antigen MLA1; Ocular melanoma-associated antigen; OMA81H; Tetraspanin-30; Tspan-30

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基因别名: C75951; CD63; LAMP-3; ME491; MLA1; OMA81H; TSPAN30

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UniProt ID: (Human) P08962, (Mouse) P41731

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Entrez Gene ID: (Human) 967, (Mouse) 12512

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功能

protein binding protein complex binding

参与通路