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Invitrogen
ABCA4 Monoclonal Antibody (3F4)
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产品信息
MA5-33095
产品规格
种属反应
Bovine,
Human,
Mouse,
Xenopus
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
3F4
抗原
Partially purified bovine 220-kDa disc rim protein
偶联物
形式
Liquid
浓度
~1 mg/mL
纯化类型
Protein G
保存液
10mM HEPES, pH 7.5, with 100µg/mL BSA, 50% glycerol, 0.15M NaCl
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Excitation: 405 nm; Emission: 645 nm; Laser: Blue Laser
靶标信息
ABCA4 (ATP-Binding Cassette, Subfamily A, Member 4), also known as ABCR, is a protein which in humans is encoded by the ABCA4 gene. ABCA4 is a member of the ATP-binding cassette transporter gene sub-family A (ABC1) found exclusively in multicellular eukaryotes. Using a whole genome radiation hybrid panel, this gene is mapped to 1p21-p13. And this gene is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Additionally, it is showed by immunofluorescence microscopy and Western blot analysis that ABCR is present in foveal and peripheral cone, as well as rod, photoreceptors. The results suggested that the loss in central vision experienced by patients with Stargardt macular dystrophy arises directly from ABCR-mediated foveal cone degeneration.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATP binding cassette transporter; ATP-binding cassette 10; ATP-binding cassette sub-family A member 4; ATP-binding cassette transporter, retinal-specific; ATP-binding cassette, sub-family A (ABC1), member 4; ATP-binding cassette, sub-family A, member 4; ATP-binding transporter, retina-specific; photoreceptor rim protein; retina-specific ABC transporter; retinal ABCA4 transporter; Retinal-specific ATP-binding cassette transporter; Retinal-specific phospholipid-transporting ATPase ABCA4; RIM ABC transporter; RIM protein; RIM proteinv; Stargardt disease protein
基因别名: ABC10; ABCA4; ABCR; ARMD2; AW050280; CORD3; D430003I15Rik; FFM; RMP; RP19; STGD; STGD1; XELAEV_180233141mg
UniProt ID: (Human) P78363, (Bovine) F1MWM0, (Mouse) O35600
Entrez Gene ID: (Human) 24, (Bovine) 281584, (Mouse) 11304, (Xenopus) 497268
phospholipid-translocating ATPase activity
transporter activity
eye pigment precursor transporter activity
ATP binding
ATPase activity, coupled to transmembrane movement of substances
nucleotide binding
phospholipid transporter activity
ATPase activity
cholesterol transporter activity
ATP-binding cassette (ABC) transporter
primary active transporter
transporter
