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Invitrogen
ABCB11 Polyclonal Antibody
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ABCB11 Antibody (PA5-27742) in ICC/IF
ABCB11 Polyclonal Antibody detects ABCB11 protein at membrane by immunofluorescent analysis. Sample: A431 cells were fixed in ice-cold MeOH for 5 min. Green: ABCB11 protein stained by ABCB11 Polyclonal Antibody (Product # PA5-27742) diluted at 1:500. Blue: Hoechst 33343 staining.
产品信息
PA5-27742
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
C. elegans,
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the Intracellular domain of human BSEP. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1.17 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: Jurkat.
Predicted reactivity: Mouse (85%), Rat (87%), Dog (84%), Cat (87%), Rabbit (85%), Bovine (88%), Guinea pig (81%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
ABCB11 is involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. It is expressed predominatly, if not exclusively, in the liver, where it is further localized to the canilicular microvilli and to subcanilicular vesicles fo the hepatocytes. Structurally, ABCB11 is a multifunctional polypeptide with two homologus halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis 2 (PFIC2). PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ABC member 16, MDR/TAP subfamily; ATP-binding cassette sub-family B member 11; ATP-binding cassette, sub-family B (MDR/TAP), member 11; Bile salt export pump; progressive familial intrahepatic cholestasis 2; sister p-glycoprotein
基因别名: ABC16; ABCB11; BRIC2; BSEP; PFIC-2; PFIC2; PGY4; SPGP
UniProt ID: (Human) O95342
Entrez Gene ID: (Human) 8647
