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Invitrogen
ABCG4 Polyclonal Antibody
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FIGURE: 1 / 1
ABCG4 Antibody (PA5-89928) in WB
Western blot analysis of ABCG4 in extracts of various cell lines. Samples were incubated with ABCG4 Polyclonal antibody (Product # PA5-89928) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.
Product Details
PA5-89928
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 270-370 of human ABCG4 (NP_0714522)
Conjugate
Form
Liquid
Concentration
1.3 mg/mL
Amount
130 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KLYILSQGQC IFKGVVTNLI PYLKGLGLHC PTYHNPADFI IEVASGEYGD LNPMLFRAVQ NGLCAMAEKK SSPEKNEVPA PCPPCPPEVD PIESHTFATS T; Positive Samples: U-87MG, A-549, U937, Mouse brain, Rat brain; Cellular Location: Membrane, Multi-pass membrane protein
Target Information
The ABCG4 gene encodes the ATP-binding cassette sub-family G member 4, a protein that is part of the ABC transporter family involved in the transport of various molecules across cellular membranes. ABC transporters play essential roles in lipid transport, drug resistance, and the maintenance of cellular homeostasis. ABCG4, specifically, is known to be involved in the transport of cholesterol and other lipids, influencing lipid homeostasis and potentially impacting processes such as cholesterol efflux and cellular lipid balance. This protein is expressed in specific tissues, including the brain and retina, indicating its role in neuronal lipid metabolism and health. While its exact physiological functions are still being elucidated, alterations in ABCG4 expression or function may be implicated in lipid-related disorders and neurodegenerative diseases, where lipid metabolism plays a crucial part. Research into ABCG4 focuses on understanding its transport mechanisms and potential contributions to pathological states, aiming to develop targeted therapies that address imbalances in lipid and cholesterol metabolism.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-binding cassette sub-family G member 4; ATP-binding cassette subfamily G member 4; ATP-binding cassette transporter White2; ATP-binding cassette, sub-family G (WHITE), member 4; putative ABC transporter; unnamed protein product
Gene Aliases: 6430517O04Rik; ABCG4; WHITE2
UniProt ID: (Human) Q9H172, (Mouse) Q91WA9, (Rat) D3ZCM3
Entrez Gene ID: (Human) 64137, (Mouse) 192663, (Rat) 300664
nucleotide binding
protein binding
ATP binding
ATPase activity
sterol-transporting ATPase activity
identical protein binding
protein homodimerization activity
protein heterodimerization activity
protein dimerization activity
ABC-type transporter activity
ATP-binding cassette (ABC) transporter
primary active transporter
transporter
regulation of transcription, DNA-templated
lipid transport
positive regulation of cholesterol efflux
sterol transport
cholesterol efflux
cholesterol homeostasis
positive regulation of cholesterol biosynthetic process
transmembrane transport
cellular response to high density lipoprotein particle stimulus
cellular response to leukemia inhibitory factor
metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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