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Invitrogen
ACVR1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA1-41185
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to amino acids 475-525 of human ACVR1.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS with 0.2% gelatin
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
By Western blot, this antibody detects a ~54 kDa band representing Activin Receptor Type IA.
Additional non-specific bands at ~14 and 27 kDa may also be detected in human kidney samples.
Suggested positive control: human kidney protein or tissue.
Target Information
Activin A receptor, type I (ACVR1) belongs to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. ACVR1 signals a specific transcriptional response in concert with activin type II receptors. The ACVR1 gene encodes activin A type I receptor, which signals a particular transcriptional response in concert with activin type II receptors. Mutations in ACVR1 have been linked to Fibrodysplasia Ossificans Progressiva (FOP), a rare genetic disorder characterized by the formation of bone in muscles, tendons, and other connective tissues, as well as Epicanthus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activin A receptor, type 1; Activin receptor type I; Activin receptor type-1; Activin receptor-like kinase 2; activin type I receptor; ACTR-I; ALK-2; ALK2-B; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSK-7L; TSR-I
Gene Aliases: ActR-I; ActRIA; Acvr; ACVR1; ACVRLK2; Alk-2; ALK2; Alk8; D330013D15Rik; SKR1; Tgfb1; Tsk7L
UniProt ID: (Rat) P80201, (Mouse) P37172
Entrez Gene ID: (Rat) 79558, (Mouse) 11477
protein kinase activity
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
transforming growth factor beta receptor activity, type I
ATP binding
activin receptor activity, type I
growth factor binding
protein homodimerization activity
SMAD binding
metal ion binding
activin binding
transforming growth factor beta binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
serine/threonine protein kinase receptor
G1/S transition of mitotic cell cycle
patterning of blood vessels
urogenital system development
in utero embryonic development
gastrulation with mouth forming second
mesoderm formation
neural crest cell migration
acute inflammatory response
embryonic heart tube morphogenesis
mitral valve morphogenesis
atrial septum primum morphogenesis
protein phosphorylation
transforming growth factor beta receptor signaling pathway
germ cell development
determination of left/right symmetry
gastrulation
mesoderm development
heart development
negative regulation of signal transduction
positive regulation of pathway-restricted SMAD protein phosphorylation
peptidyl-threonine phosphorylation
signal transduction by protein phosphorylation
regulation of ossification
positive regulation of bone mineralization
BMP signaling pathway
activin receptor signaling pathway
negative regulation of activin receptor signaling pathway
positive regulation of osteoblast differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of skeletal muscle tissue development
smooth muscle cell differentiation
pharyngeal system development
pathway-restricted SMAD protein phosphorylation
cardiac muscle cell fate commitment
endocardial cushion cell fate commitment
cellular response to glucocorticoid stimulus
positive regulation of determination of dorsal identity
negative regulation of extrinsic apoptotic signaling pathway
transmembrane receptor protein serine/threonine kinase signaling pathway
embryo development
phosphorylation
intracellular signal transduction
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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