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Invitrogen
ADAM10 Monoclonal Antibody (139712)
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产品信息
MA5-23867
产品规格
种属反应
Mouse
宿主/亚型
Rat
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
139712
抗原
Sf 21-derived recombinant mouse ADAM10 Thr215-Glu673
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In direct ELISAs, approximately 25% cross-reactivity with recombinant human (rh) rhADAM10 is observed and no cross-reactivity with rhADAM8, recombinant mouse (rm) ADAM9, rmADAM15, rhBACE, or rhTACE is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
靶标信息
Proinflammatory cytokine tumor necrosis factor-a (TNF-a) contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-a, notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-a, notch and its ligand delta (1-3). The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ), and MADM, respectively. ADAM10 mRNA is expressed in a variety of human and bovine tissues.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: a disintegrin and metalloprotease domain (ADAM) 10; a disintegrin and metalloprotease domain 10; a disintegrin and metalloproteinase; ADAM; ADAM 10; ADAMs; CD156c; Disintegrin and metalloproteinase domain-containing protein 10; Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease; metalloendopeptidases
基因别名: 1700031C13Rik; Adam10; Kuz; kuzbanian; MADM
UniProt ID: (Mouse) O35598
Entrez Gene ID: (Mouse) 11487
in utero embryonic development
protein phosphorylation
proteolysis
membrane protein ectodomain proteolysis
nucleocytoplasmic transport
negative regulation of cell adhesion
Notch signaling pathway
Notch receptor processing
positive regulation of cell proliferation
positive regulation of T cell chemotaxis
positive regulation of cell growth
positive regulation of cell migration
response to tumor necrosis factor
monocyte activation
PMA-inducible membrane protein ectodomain proteolysis
constitutive protein ectodomain proteolysis
