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Invitrogen
ADAMTS1 Polyclonal Antibody
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ADAMTS1 Antibody (PA5-47790) in IHC (F)
Immunohistochemical analysis of ADAMTS1 in immersion fixed frozen sections of mouse embryo (13 d.p.c.). Samples were incubated in ADAMTS1 polyclonal antibody (Product # PA5-47790) using a dilution of 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Sheep HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cartilage primordium... View More
产品信息
PA5-47790
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Mouse
宿主/亚型
Sheep
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CHO-derived recombinant mouse ADAMTS1 Phe254-Cys725
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In direct ELISAs, less than 5% cross-reactivity with recombinant human (rh) ADAMTS4 and rhADAMTS15 is observed and less than 1% cross-reactivity with rhADAMTSL1.2, rhADAMTSL2, rhADAMTS5, rhADAMTS8, rhADAMTS10, rhADAMTS12, rhADAMTS13, and rhADAMTS16 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
ADAMTS-1 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: a disintegrin and metalloproteinase; A disintegrin and metalloproteinase with thrombospondin motifs 1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1; ADAM; ADAM-TS 1; ADAM-TS1; ADAMs; ADAMTS-1; ADAMTS1; extracellular protein with metalloprotease and TSP domains; human metalloproteinase with thrombospondin type 1 motifs; metalloendopeptidases; metalloprotease and thrombospondin-1; METH-1; unnamed protein product
基因别名: ADAM-TS1; ADAMTS; ADAMTS-1; ADAMTS1; C3-C5; KIAA1346; METH-1; METH1
UniProt ID: (Human) Q9UHI8, (Mouse) E9QMN9
Entrez Gene ID: (Human) 9510, (Mouse) 11504
ovulation from ovarian follicle
kidney development
proteolysis
integrin-mediated signaling pathway
negative regulation of cell proliferation
negative regulation of angiogenesis
extracellular matrix organization
heart trabecula formation
positive regulation of G1/S transition of mitotic cell cycle
positive regulation of vascular smooth muscle cell proliferation
positive regulation of vascular associated smooth muscle cell migration
positive regulation of neuron projection development
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