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Invitrogen
ADORA2A/ADORA2B Monoclonal Antibody (599743)
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产品信息
MA5-62032
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
599743
抗原
NS0 mouse myeloma cell line transfected with human Adenosine A2aR, Met1-Ser412
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 0.5 mg/mL in sterile PBS.
靶标信息
ADORA2A (Adenosine A2A Receptor) and ADORA2B (Adenosine A2B Receptor) are genes that encode G protein-coupled receptors (GPCRs) involved in the adenosine signaling pathway. These receptors play critical roles in various physiological processes by mediating the effects of adenosine, a nucleoside that functions as a signaling molecule. ADORA2A is predominantly expressed in the central nervous system, particularly in the brain, where it modulates neurotransmitter release, neuroprotection, and neuroinflammation. It has been implicated in neurological conditions such as Parkinson's disease, where its antagonists are being explored as potential therapeutic agents. ADORA2B, on the other hand, is more widely distributed in peripheral tissues, including the cardiovascular system, lungs, and immune cells. It is involved in regulating inflammatory responses, vascular tone, and tissue protection during hypoxic conditions. Dysregulation of ADORA2B signaling has been linked to various pathological conditions, including chronic inflammation, asthma, and ischemic injury. Understanding the distinct and overlapping roles of ADORA2A and ADORA2B is crucial for developing targeted therapies aimed at modulating adenosine signaling in diverse diseases. Research into these receptors provides valuable insights into their potential as therapeutic targets for treating neurological disorders, cardiovascular diseases, and inflammatory conditions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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