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Invitrogen
ADORA2B Polyclonal Antibody
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ADORA2B Antibody (PA5-77849) in IHC (P)
ADORA2B Polyclonal Antibody detects Adenosine A2b Receptor protein at cytoplasm in mouse brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse brain. ADORA2B Polyclonal Antibody (Product # PA5-77849) diluted at 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.
产品信息
PA5-77849
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide encompassing a sequence within the Extracellular domain of human Adenosine A2b Receptor. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
0.53 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Control: U87-MG, SK-N-SH, IMR32, SK-N-AS, mouse brain, rat brain
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
ADORA2B encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: A2b receptor; A2b, Rs; Adenosine receptor A2b; HGNC:264; netrin-1 receptor
基因别名: A2b; A2BAR; A2BR; AA2BR; ADORA2; ADORA2B; AI480866; AI605384
UniProt ID: (Human) P29275, (Rat) P29276, (Mouse) Q60614
Entrez Gene ID: (Human) 136, (Rat) 29316, (Mouse) 11541
activation of MAPK activity
adenosine receptor signaling pathway
positive regulation of chronic inflammatory response to non-antigenic stimulus
cellular defense response
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
JNK cascade
excretion
positive regulation of vascular endothelial growth factor production
positive regulation of guanylate cyclase activity
cellular response to extracellular stimulus
positive regulation of chemokine production
positive regulation of interleukin-6 production
positive regulation of mast cell degranulation
cellular protein metabolic process
relaxation of vascular smooth muscle
positive regulation of cell proliferation
negative regulation of cell proliferation
positive regulation of norepinephrine secretion
positive regulation of steroid biosynthetic process
positive regulation of cAMP biosynthetic process
positive regulation of cGMP biosynthetic process
negative regulation of collagen biosynthetic process
positive regulation of catecholamine secretion
regulation of angiogenesis
positive regulation of vasodilation
signal transduction
