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Abnova
ADRB2 Polyclonal Antibody, MaxPab™
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00000154-D01P
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ADRB2 (NP_000015.1, 1 a.a. approximately 413 a.a) full-length human protein.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5-1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MGQPGNGSAF LLAPNRSHAP DHDVTQQRDE VWVVGMGIVM SLIVLAIVFG NVLVITAIAK FERLQTVTNY FITSLACADL VMGLAVVPFG AAHILMKMWT FGNFWCEFWT SIDVLCVTAS IETLCVIAVD RYFAITSPFK YQSLLTKNKA RVIILMVWIV SGLTSFLPIQ MHWYRATHQE AINCYANETC CDFFTNQAYA IASSIVSFYV PLVIMVFVYS RVFQEAKRQL QKIDKSEGRF HVQNLSQVEQ DGRTGHGLRR SSKFCLKEHK ALKTLGIIMG TFTLCWLPFF IVNIVHVIQD NLIRKEVYIL LNWIGYVNSG FNPLIYCRSP DFRIAFQELL CLRRSSLKAY GNGYSSNGNT GEQSGYHVEQ EKENKLLCED LPGTEDFVGH QGTVPSDNID SQGRNCSTND SLL
靶标信息
Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family. Nine receptor subtypes have been identified thus far including three alpha-1 AR subtypes (1A/D, 1B, and 1C), three alpha-2 ARs (2A, 2B, and 2C), and three beta AR subtypes (1, 2, and 3). ARs participate in either the onset or maintenance of several disease states including hypertension, cardiac dysfunction (congestive heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: adrenergic, beta-2-, receptor, surface; adrenoceptor beta 2 surface; AR beta2; beta 2-AR; beta-2 adrenoceptor; beta-2 adrenoreceptor; beta2-Adrenoreceptor; catecholamine receptor; HGNC:286; putative; unnamed protein product
基因别名: Adrb-2; ADRB2R; ADRBR; ARB2; B2AR; Badm; BAR; BETA2AR; Gpcr7
UniProt ID: (Human) P07550, (Mouse) P18762
Entrez Gene ID: (Human) 154, (Mouse) 11555
beta-amyloid binding
G-protein coupled receptor activity
adrenergic receptor activity
beta-adrenergic receptor activity
beta2-adrenergic receptor activity
protein binding
adenylate cyclase binding
potassium channel regulator activity
enzyme binding
identical protein binding
protein homodimerization activity
macromolecular complex binding
norepinephrine binding
G-protein alpha-subunit binding
B2 bradykinin receptor binding
ionotropic glutamate receptor binding
protein phosphatase 2A binding
receptor-receptor interaction
regulation of systemic arterial blood pressure by norepinephrine-epinephrine
diet induced thermogenesis
vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
regulation of sodium ion transport
diaphragm contraction
positive regulation of the force of heart contraction by epinephrine
receptor-mediated endocytosis
regulation of smooth muscle contraction
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
regulation of heart contraction
positive regulation of cell proliferation
associative learning
response to cold
positive regulation of cardiac muscle cell apoptotic process
negative regulation of cardiac muscle cell apoptotic process
positive regulation of sodium ion transport
negative regulation of angiogenesis
negative regulation of ossification
positive regulation of bone mineralization
heat generation
positive regulation of ATPase activity
synaptic transmission, glutamatergic
negative regulation of urine volume
negative regulation of multicellular organism growth
vasodilation
positive regulation of apoptotic process
positive regulation of potassium ion transport
positive regulation of MAPK cascade
bone resorption
negative regulation of G-protein coupled receptor protein signaling pathway
positive regulation of transcription from RNA polymerase II promoter
negative regulation of smooth muscle contraction
positive regulation of skeletal muscle tissue growth
brown fat cell differentiation
regulation of calcium ion transport
excitatory postsynaptic potential
positive regulation of mini excitatory postsynaptic potential
cellular response to hypoxia
response to catecholamine
adrenergic receptor signaling pathway
adenylate cyclase-activating adrenergic receptor signaling pathway
adenylate cyclase-inhibiting adrenergic receptor signaling pathway
regulation of blood vessel diameter
AMPA selective glutamate receptor signaling pathway
presynaptic modulation of chemical synaptic transmission
positive regulation of cardiac muscle cell contraction
positive regulation of cold-induced thermogenesis
positive regulation of cAMP/PKA signal transduction
positive regulation of glutamate receptor signaling pathway
positive regulation of autophagosome maturation
positive regulation of lipophagy
cellular response to beta-amyloid
positive regulation of calcium ion import across plasma membrane
cell surface receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
endosome to lysosome transport
response to psychosocial stress
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