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Invitrogen
AFG3L2 Polyclonal Antibody
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AFG3L2 Antibody (PA5-90436) in IHC (P)
Immunohistochemistry analysis of AFG3L2 in paraffin-embedded human colon carcinoma. Samples were incubated with AFG3L2 Polyclonal antibody (Product # PA5-90436) using a dilution of 1:50 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-90436
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 538-797 of human AFG3L2 (NP_0067872)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.65 mg/mL
规格
65 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: DSINQKHFEQ AIERVIGGLE KKTQVLQPEE KKTVAYHEAG HAVAGWYLEH ADPLLKVSII PRGKGLGYAQ YLPKEQYLYT KEQLLDRMCM TLGGRVSEEI FFGRITTGAQ DDLRKVTQSA YAQIVQFGMN EKVGQISFDL PRQGDMVLEK PYSEATARLI DDEVRILIND AYKRTVALLT EKKADVEKVA LLLLEKEVLD KNDMVELLGP RPFAEKSTYE EFVEGTGSLD EDTSLPEGLK DWNKEREKEK EEPPGEKVAN; Positive Samples: LO2, 293T, HeLa, Mouse brain, Mouse heart, Mouse kidney, Mouse liver, Mouse pancreas; Cellular Location: Mitochondrion membrane, Multi-pass membrane protein
靶标信息
AFG3L2 is a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. AFG3L2 gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders. This gene encodes a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. This gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AFG3 (ATPase family gene 3)-like 2; AFG3 ATPase family gene 3-like 2; AFG3 ATPase family member 3-like 2; AFG3 like AAA ATPase 2; AFG3-like AAA ATPase 2; AFG3-like protein 2; ATPase family gene 3, yeast; FLJ25993; paraplegin-like protein; unnamed protein product
基因别名: 2310036I02Rik; Emv66; OPA12; par; SCA28; SPAX5
UniProt ID: (Human) Q9Y4W6, (Mouse) Q8JZQ2
Entrez Gene ID: (Human) 10939, (Rat) 307350, (Mouse) 69597
proteolysis
mitochondrion organization
axonogenesis
neuromuscular junction development
mitochondrial fusion
biological_process
protein processing
protein autoprocessing
nerve development
protein catabolic process
membrane protein proteolysis
mitochondrial protein processing
calcium ion transmembrane import into mitochondrion
regulation of multicellular organism growth
cristae formation
myelination
mitochondrial calcium ion homeostasis
protein maturation
muscle cell development
righting reflex
cellular response to glutathione
regulation of calcium import into the mitochondrion
mitochondrial protein quality control
glutathione import into mitochondrion
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