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Invitrogen
AGO1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-139888
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.1 mg/mL
规格
10 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
Immunogen sequence: HLPCLQVGQE QKHTYLPLEV CNIVAGQRCI KKLTDNQTST MIKATARSAP DRQEEIS
Highest antigen sequence indentity to the following orthologs: Rat - 100%, Mouse - 100%.
靶标信息
AGO1 is a member of the Argonaute family of proteins which play a role in RNA interference. The protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. AGO1 binds to miRNAs or siRNAs and represses the translation of mRNAs.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ARGONAUTE 1; argonaute 1, RISC catalytic component; argonaute RISC catalytic component 1; argonaute1; AtAGO1; eIF-2C 1; eIF2C 1; eukaryotic translation initiation factor 2C, 1; Golgi Endoplasmic Reticulum protein 95 kDa; ICU9; putative RNA-binding protein Q99; T1N15.2; T1N15_2; unnamed protein product
基因别名: EIF2C; EIF2C1; GERP95; hAgo1; NEDLBAS; Q99
UniProt ID: (Human) Q9UL18
Entrez Gene ID: (Human) 26523
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core binding
core promoter sequence-specific DNA binding
nucleic acid binding
RNA binding
double-stranded RNA binding
single-stranded RNA binding
endoribonuclease activity
protein binding
miRNA binding
nuclear-transcribed mRNA catabolic process
negative regulation of angiogenesis
pre-miRNA processing
posttranscriptional gene silencing by RNA
production of miRNAs involved in gene silencing by miRNA
miRNA mediated inhibition of translation
mRNA cleavage involved in gene silencing by miRNA
regulation of mRNA stability
positive regulation of transcription from RNA polymerase II promoter
small RNA loading onto RISC
mRNA cleavage involved in gene silencing by siRNA
positive regulation of NIK/NF-kappaB signaling
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