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Invitrogen
AGR2 Recombinant Rabbit Monoclonal Antibody (6M5B1)
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AGR2 Antibody (MA5-35170) in ICC/IF
Confocal imaging (Immunocytochemistry) of AGR2 in NIH/3T3 cells. Samples were incubated with AGR2 Monoclonal antibody (Product # MA5-35170) using a dilution of 1:100 (Green). The cells were counterstained with Alpha-tubulin (ubiquitous) chain Rabbit mAb (dilution 1:100) (Red). DAPI was used for nuclear staining (blue). Objective: 60x.
产品信息
MA5-35170
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
6M5B1
抗原
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human AGR2 (O95994)
偶联物
形式
Liquid
浓度
0.93 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MEKIPVSAFL LLVALSYTLA RDTTVKPGAK KDTKDSRPKL PQTLSRGWGD QLIWTQTYEE ALYKSKTSNK PLMIIHHLDE CPHSQALKKV FAENKEIQKL
靶标信息
AGR2 (anterior gradient protein 2) and AGR3 are members of the anterior gradient homolog family. They are secreted cytoplasmic proteins which are involved in metastasis induction and p53 tumour supressor inhibition. They may serve as molecular markers and potential therapeutic targets for hormone-responsive breast tumours. AGR2 is ubiquitously expressed with upregulated expression in prostate cancer, breast cancer, lung cancer, renal carcinomas and endometrial carcinomas. AGR2 expression is positively correlated with that of the estrogen receptor (ER) and is negatively correlated with that of the epidermal growth factor receptor (EGFR).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: AG-2; anterior gradient 2 homolog; anterior gradient homolog 2; Anterior gradient protein 2 homolog; epididymis secretory protein Li 116; HPC8; protein disulfide isomerase family A, member 17; Protein Gob-4; secreted cement gland homolog; Secreted cement gland protein XAG-2 homolog
基因别名: AG2; AGR2; Agr2h; GOB-4; Gob4; HAG-2; HEL-S-116; mAG-2; PDIA17; UNQ515/PRO1030; XAG-2
UniProt ID: (Human) O95994, (Mouse) O88312
Entrez Gene ID: (Human) 10551, (Mouse) 23795
positive regulation of gene expression
positive regulation of cell-substrate adhesion
response to endoplasmic reticulum stress
positive regulation of epidermal growth factor receptor signaling pathway
digestive tract morphogenesis
positive regulation of developmental growth
lung goblet cell differentiation
negative regulation of cell death
mucus secretion
positive regulation of establishment of protein localization to plasma membrane
positive regulation of IRE1-mediated unfolded protein response
positive regulation of PERK-mediated unfolded protein response
