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Abnova
AKAP12 Monoclonal Antibody (1C5)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00009590-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
1C5
抗原
AKAP12 (NP_005091, 1675 a.a. approximately 1782 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.44 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: VPEDDGHALL AERIEKSLVE PKEDEKGDDV DDPENQNSAL ADTDASGGLT KESPDTNGPK QKEKEDAQEV ELQEGKVHSE SDKAITPQAQ EELQKQERES AKSELTES
靶标信息
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: A kinase (PRKA) anchor protein 12; A-kinase anchor protein, 250kDa; kinase scaffold protein gravin; myasthenia gravis autoantigen gravin; Src-Suppressed C Kinase Substrate
基因别名: AKAP250; SSeCKS
UniProt ID: (Human) Q02952
Entrez Gene ID: (Human) 9590
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
response to lipopolysaccharide
positive regulation of tumor necrosis factor production
hepatic stellate cell activation
negative regulation of vascular permeability
response to electrical stimulus
positive regulation of hepatic stellate cell migration
positive regulation of ERK1 and ERK2 cascade
cellular response to interleukin-1
cellular response to tumor necrosis factor
regulation of protein kinase C signaling
cAMP/PKA signal transduction
positive regulation of oligodendrocyte apoptotic process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
