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Invitrogen
AKR1C1 Polyclonal Antibody
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AKR1C1 Antibody (PA5-120192) in WB
Western blot analysis of AKR1C1 in extracts of various cell lines. Samples were incubated with AKR1C1 Polyclonal antibody (Product # PA5-120192) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-120192
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human AKR1C1 (NP_001344.2).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.22 mg/mL
规格
22 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive test controls include: HeLa, 22Rv1, U-87MG, Mouse liver. The target is usually found in the following locations: Cytoplasm.
Immunogen sequence: MDSKYQCVKL NDGHFMPVLG FGTYAPAEVP KSKALEATKL AIEAGFRHID SAHLYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWCNSH RPELVRPALE RSLKNLQLDY VDLYLIHFPV SVKPGEEVIP KDENGKILFD TVDLCATWEA VEKCKDAGLA KSIGVSNFNR RQLEMILNKP GLKYKPVCNQ VECHPYFNQR KLLDFCKSKD IVLVAYSALG SHREEPWVDP NSPVLLEDPV LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTS EEMKAIDGLN RNVRYLTLDI FAGPPNYPFS DEY
靶标信息
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 17-beta-HSD 5; 17HSD type 5; 20-alpha-HSD; 20alpha-hydroxysteroid dehydrogenase; 3beta-hydroxysteroid 3-dehydrogenase; Aldo-keto reductase family 1 member C1; aldo-keto reductase family 1, member C1 (aldehyde reductase); Chlordecone reductase homolog HAKRC; DD1; Dihydrodiol dehydrogenase 1; Estradiol 17 beta-dehydrogenase 5; estradiol 17-beta-dehydrogenase (A-specific); HBAB; High-affinity hepatic bile acid-binding protein; hydroxysteroid 17-beta dehydrogenase 5; RP11-69D4.1
基因别名: 3alpha-HSD; AKR1C1; Akr1c6; DDH; DDH1; Hsd17b5
UniProt ID: (Mouse) P70694
Entrez Gene ID: (Mouse) 83702
C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity
retinal dehydrogenase activity
aldo-keto reductase (NADP) activity
estradiol 17-beta-dehydrogenase activity
isocitrate dehydrogenase activity
mevaldate reductase activity
gluconate dehydrogenase activity
steroid dehydrogenase activity
oxidoreductase activity
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
epoxide dehydrogenase activity
5-exo-hydroxycamphor dehydrogenase activity
2-hydroxytetrahydrofuran dehydrogenase activity
acetoin dehydrogenase activity
phenylcoumaran benzylic ether reductase activity
D-xylose:NADP reductase activity
L-arabinose:NADP reductase activity
D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
steroid dehydrogenase activity, acting on the CH-CH group of donors
(R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity
3-hydroxymenthone dehydrogenase activity
very long-chain-3-hydroxyacyl-CoA dehydrogenase activity
dihydrotestosterone 17-beta-dehydrogenase activity
(R)-2-hydroxyisocaproate dehydrogenase activity
L-arabinose 1-dehydrogenase (NADP+) activity
L-xylulose reductase (NAD+) activity
17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
androsterone dehydrogenase activity
testosterone 17-beta-dehydrogenase (NADP+) activity
3-ketoglucose-reductase activity
(R)-2-hydroxyglutarate dehydrogenase activity
D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity
oxidoreductase
reductase
metabolite interconversion enzyme
lipid metabolic process
steroid biosynthetic process
steroid metabolic process
response to drug
response to estrogen
daunorubicin metabolic process
doxorubicin metabolic process
negative regulation of mRNA splicing, via spliceosome
oxidation-reduction process
cellular response to jasmonic acid stimulus
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