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Invitrogen
AKT2 Monoclonal Antibody (4H7)
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图: 1 / 9
AKT2 Antibody (MA1-034) in ICC/IF
Immunofluorescent analysis of AKT2 (green) showing staining in the cytoplasm and nucleus of C2C12 cells (right) compared to a negative control without primary antibody (left). Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with an AKT2 monoclonal antibody (Product # MA1-034) in 3% BSA-PBS at a dilution of 1:20 and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLig... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA1-034
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
4H7
抗原
Full length human recombinant protein of human AKT2 (NP_001617) produced in HEK293T cell.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS with 1mg/mL BSA, 30% glycerol
内含物
0.05% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
AKT2 is a phosphoinositide-dependent serine/threonine protein kinase that is enriched in insulin responsive tissues and has been implicated in the metabolic actions of the hormone. Akt is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activate phosphatidylinositol 3-kinase (PI 3-kinase). Akt2 is amplified and overexpressed in some human cancers.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AKT2 kinase; murine thymoma viral (v-akt) oncogene homolog 2; PKB beta; Protein kinase Akt-2; Protein kinase B beta; protein kinase B, beta; RAC protein kinase beta; RAC protein kinase beta RAC-PK beta; RAC-beta serine/threonine protein kinase; RAC-beta serine/threonine-protein kinase; RAC-PK-beta; thymoma viral proto-oncogene 2
基因别名: 2410016A19Rik; AKT2; AW554154; PKB; PKBbeta
UniProt ID: (Rat) P47197, (Mouse) Q60823
Entrez Gene ID: (Rat) 25233, (Mouse) 11652
protein kinase activity
protein serine/threonine kinase activity
protein kinase C binding
protein binding
ATP binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
protein modifying enzyme
positive regulation of protein phosphorylation
glycogen biosynthetic process
glucose metabolic process
regulation of translation
protein phosphorylation
response to osmotic stress
multicellular organism development
insulin receptor signaling pathway
carbohydrate transport
positive regulation of signal transduction
positive regulation of gene expression
negative regulation of plasma membrane long-chain fatty acid transport
positive regulation of sodium ion transport
positive regulation of glucose metabolic process
response to muscle activity
positive regulation of cell migration
positive regulation of vesicle fusion
response to nutrient levels
positive regulation of fatty acid beta-oxidation
peripheral nervous system myelin maintenance
response to insulin
cellular response to insulin stimulus
cellular response to hormone stimulus
negative regulation of RNA splicing
positive regulation of peptidyl-serine phosphorylation
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
protein kinase B signaling
positive regulation of nitric oxide biosynthetic process
positive regulation of glycogen biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
positive regulation of glucose import
positive regulation of positive chemotaxis
intracellular protein transmembrane transport
cellular response to organic cyclic compound
protein localization to plasma membrane
positive regulation of protein targeting to membrane
positive regulation of cell motility
positive regulation of glucose import in response to insulin stimulus
carbohydrate metabolic process
glycogen metabolic process
transport
apoptotic process
phosphorylation
activation of GTPase activity
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