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Abnova
ALS2CR8 Polyclonal Antibody, MaxPab™
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产品信息
H00079800-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ALS2CR8 (NP_079020.12, 1 a.a. approximately 718 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5-1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MEQSNDSLRV NHNDGEESKT SAQVFEHLIC MDSRDSSFGQ NDSPTVLPIT TREANNSLIS QNIPGPLTQT QTLSAEQFHL VDQNGQAIQY ELQSLGESNA QMMIVASPTE NGQVLRVIPP TQTGMAQVII PQGQLVDVNS PRDVPEEKPS NRNLPTVRVD TLADNTSNYI LHPQTSFPLP KKSVTGMLEE PLLGPLQPLS SNTPIWACRL RSCEKIGDSY RGYCVSETEL ESVLTFHKQQ TQSVWGTRQS PSPAKPATRL MWKSQYVPYD GIPFVNAGSR AVVMECQYGP RRKGFQLKKV SEQESRSCQL YKATCPARIY IKKVQKFPEY RVPTDPKIDK KIIRMEQEKA FNMLKKNLVD AGGVLRWYVQ LPTQQAHQYH ELETPCLTLS PSPFPVSSLE EEETAVRDEN CALPSRLHPQ VAHKIQELVS QGIEQVYAVR KQLRKFVERE LFKPDEVPER HNLSFFPTVN DIKNHIHEVQ KSLRNGDTVY NSEIIPATLQ WTTDSGNILK ETMTVTFAEG NSPGESITTK VETNQTRGSL SPEPTHLLSS LSSFQPKIFT QLQGLQLQPR YTSPDESPAV VSVNNQPSSS PSGLLDTIGS AVMNNNSLLL GQSHSLQRDT CLTQNNSTAS TMGNLPEPDQ NLVAMDELVE VGDVEDTGNL EGTVHRILLG DVQTIPIQII DNHSALIEEN PESTISVSQV KQEPKEPALS MEAKNCGL
靶标信息
CARF (calcium-response factor), also known as ALS2CR8 (amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein) or NYD-SP24, is a 725 amino acid nuclear protein. Expressed in a wide variety of tissues with highest expression in the hippocampus, CARF is thought to be a transcription factor that associates with the p53 tumor suppression pathway. CARF cooperates, co-localizes and is co-regulated with ARF, an ADP-ribosylation factor, and, through this interaction, helps to mediate ARF-p53-induced apoptotic signaling. This apoptotic pathway is implicated in cell cycle control, proper cellular development, response to DNA damage and the aging process, suggesting that CARF participates in various events throughout the cell.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein; Calcium-response factor; Calcium-responsive transcription factor; CaRF; Testis development protein NYD-SP24
基因别名: ALS2CR8; CARF; NYD-SP24
UniProt ID: (Human) Q8N187
Entrez Gene ID: (Human) 79800
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
DNA-binding transcription factor
gene-specific transcriptional regulator
