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Invitrogen
AMER1 Polyclonal Antibody
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产品信息
PA5-64204
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: RDSPLSLYTE PPGAYDWPAW APCPLPVGPG PAWISPNQLD RPSSQSPYRQ ATCCIPPMTM SISLSVPESR APGESGPQLA RPSHLHLP
Highest antigen sequence identity to the following orthologs: Mouse - 69%, Rat - 69%.
靶标信息
The AMER1 gene encodes the protein APC membrane recruitment 1, also known as Wilms tumor 1-associating protein (WT1-associating protein). This protein plays a significant role in the Wnt signaling pathway, which is critical for cellular processes such as proliferation, differentiation, and migration. AMER1 interacts with the adenomatous polyposis coli (APC) protein and is involved in the regulation of β-catenin, a key mediator of Wnt signaling. By recruiting APC to the cell membrane, AMER1 facilitates the degradation of β-catenin, thereby acting as a negative regulator of the pathway. This function is vital in maintaining cellular homeostasis and preventing uncontrolled cell growth. Mutations or dysregulation of AMER1 are associated with various cancers, including colorectal cancer, as aberrant Wnt signaling can lead to oncogenesis. Moreover, germline mutations in AMER1 are linked to conditions such as osteoporosis-pseudoglioma syndrome, highlighting its role in bone development and eye health. Ongoing research focuses on elucidating the detailed mechanisms of AMER1's involvement in signaling pathways and its potential as a therapeutic target in cancer and genetic disorders.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: adenomatous polyposis coli membrane recruitment 1; Amer1; APC membrane recruitment protein 1; family with sequence similarity 123B; Protein FAM123B; RP11-403E24.2; Wilms tumor gene on the X chromosome protein; Wilms tumor on the X
基因别名: AMER1; FAM123B; OSCS; WTX
UniProt ID: (Human) Q5JTC6
Entrez Gene ID: (Human) 139285
Wnt signaling pathway
positive regulation of protein ubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
anatomical structure development
bone development
adipose tissue development
regulation of canonical Wnt signaling pathway
mesenchymal cell differentiation involved in kidney development
negative regulation of canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
positive regulation of cellular protein catabolic process
beta-catenin destruction complex assembly
beta-catenin destruction complex disassembly
