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Abnova
AMICA1 Polyclonal Antibody, MaxPab™
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产品信息
H00120425-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
AMICA1 (AAI00798.1, 1 a.a. approximately 355 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5-1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MGCVFQSTED KCIFKIDWTL SPGEHAKDEY VLYYYSNLSV PIGRFQNRVH LMGDILCNDG SLLLQDVQEA DQGTYICEIR LKGESQVFKK AVVLHVLPEE PKELMVHVGG LIQMGCVFQS TEVKHVTKVE WIFSGRRAKE EIVFRYYHKL RMSVEYSQSW GHFQNRVNLV GDIFRNDGSI MLQGVRESDG GNYTCSIHLG NLVFKKTIVL HVSPEEPRTL VTPAALRPLV LGGNQLVIIV GIVCATILLL PVLILIVKKT CGNKSSVNST VLVKNTKKTN PEIKEKPCHF ERCEGEKHIY SPIIVREVIE EEEPSEKSEA TYMTMHPVWP SLRSDRNNSL EKKSGGGMPK TQQAF
靶标信息
AMICA transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: adhesion molecule AMICA; Adhesion molecule interacting with CXADR antigen 1; adhesion molecule, interacts with CXADR antigen 1; Dendritic cell-specific protein CREA7-1; dendritic-cell specific protein CREA7-1; dendritic-cell specific protein CREA7-4; Junctional adhesion molecule-like
基因别名: AMICA; AMICA1; CREA7-1; CREA7-4; Gm638; JAML; UNQ722/PRO1387
UniProt ID: (Human) Q86YT9
Entrez Gene ID: (Human) 120425
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
neutrophil chemotaxis
monocyte extravasation
gamma-delta T cell activation
regulation of immune response
leukocyte migration
positive regulation of epithelial cell proliferation involved in wound healing
neutrophil extravasation
