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This antibody detects endogenous protein at a molecular weight of 38, 54 and 63 kDa.
Purity is >95% by SDS-PAGE.
The 5-AMP activated protein kinase (AMPK), a member of the SNF1 (sucrose non fermentor) kinase family, is a heterotrimeric protein comprise of alpha (63 kDa), beta (30 kDa) and gamma (38 kDa) subunits. The alpha subunit is the catalytic subunit, while beta and gamma are non catalytic subunits (although they have been found to interact with the active subunit in liver). AMPK regulates fatty acid and sterol synthesis by phosphorylation of acetyl-CoA as well as cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase. AMPK is activated by AMP and can be also regulated by treatment with purified protein phosphatase in vitro.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 5'-AMP-activated protein kinase subunit gamma-1; 5'-AMP-activated protein kinase subunit gamma-2; 5'-AMP-activated protein kinase subunit gamma-3; 5'-AMP-activated protein kinase, gamma-1 subunit; 5'-AMP-activated protein kinase, gamma-3 subunit; 5-AMP-activated protein kinase, gamma-2 subunit; adenosine monophosphate-activated protein kinase gamma 2-subunit; AMP-activated protein kinase gamma 3 subunit; AMP-activated protein kinase gamma subunit; AMP-activated protein kinase gamma2 subunit; AMP-activated protein kinase, noncatalytic gamma-1 subunit; ampk gamma; AMPK gamma 2; AMPK gamma-1 chain; AMPK gamma-2 chain; AMPK gamma-3 chain; AMPK gamma1; AMPK gamma2; AMPK gamma3; AMPK subunit gamma-1; AMPK subunit gamma-2; AMPK subunit gamma-3; AMPK- gamma1; AMPK- gamma2; AMPK- gamma3; AMPKg; H91620p; Protein kinase AMP-activated gamma; protein kinase, AMP-activated, gamma 1 non-catalytic subunit; protein kinase, AMP-activated, gamma 2 non-catalytic subunit; protein kinase, AMP-activated, gamma 3 non-catalytic subunit; protein kinase, AMP-activated, gamma 3 non-catatlytic subunit
基因别名: 2410051C13Rik; AA571379; AAKG; AAKG2; AI854673; Amkg3; AMPKG; AMPKG3; AMPKg3L; AMPKg3S; BB036179; CMH6; H91620p; Prkaac; PRKAG1; PRKAG2; PRKAG3; Prkga1; WPWS
UniProt ID: (Human) P54619, (Human) Q9UGJ0, (Human) Q9UGI9, (Mouse) O54950, (Rat) P80385, (Mouse) Q91WG5, (Mouse) Q8BGM7
Entrez Gene ID: (Human) 5571, (Human) 51422, (Human) 53632, (Mouse) 19082, (Rat) 25520, (Rat) 373545, (Mouse) 108099, (Rat) 301518, (Mouse) 241113
分子生物学功能: kinase modulator