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Recommended positive controls: 293T, Jurkat, Raji.
Predicted reactivity: Human (99%), Mouse (84%), Rat (83%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Ankyrin repeat and LEM domain-containing protein 2; LEM domain containing 7; LEM domain-containing protein 4
基因别名: ANKLE2; KIAA0692; LEM4; LEMD7; MCPH16
UniProt ID: (Human) Q86XL3
Entrez Gene ID: (Human) 23141