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Immunogen sequence: SWLQMFVAEAV FKKLCLQSSG SVSSEPLSLQ KMVYSYLPAL GKTGVLGSGK IQVSKKIGQR PCFDSQRTLL MLNGTKQKQV EGLP
Highest antigen sequence identity to the following orthologs - mouse 67%, rat 67%.
Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions (PubMed:25931565).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: ankyrin repeat domain 32; Ankyrin repeat domain-containing protein 32; BRCT domain containing 1; BRCT domain-containing protein 1; SMC5-SMC6 complex localization factor protein 1; Smc5/6 localization factor 1
基因别名: ANKRD32; BRCTD1; BRCTx; SLF1
UniProt ID: (Human) Q9BQI6
Entrez Gene ID: (Human) 84250