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Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome. May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511). Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis. [Uniprot]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: acidic (leucine-rich) nuclear phosphoprotein 32 family, member E; Acidic leucine-rich nuclear phosphoprotein 32 family member E; Cerebellar postnatal development protein 1; LANP-L; LANP-like protein; leucine-rich acidic nuclear protein like
基因别名: 2810018A15Rik; AI047746; AI326868; ANP32E; CPD1; LANP-L; LANPL; mLANP-L
UniProt ID: (Human) Q9BTT0, (Mouse) P97822
Entrez Gene ID: (Human) 81611, (Mouse) 66471