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Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 86%; Rat: 100%; Zebrafish: 82%
Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants. [provided by RefSeq].
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Amine oxidase [copper-containing] 2; amine oxidase copper containing 2; Amine oxidase copper-containing 2; amine oxidase, copper containing 2 (retina-specific); RAO; Retina-specific copper amine oxidase; Semicarbazide-sensitive amine oxidase; SSAO
基因别名: AOC2; DAO2; RAO
UniProt ID: (Human) O75106
Entrez Gene ID: (Human) 314