Invitrogen

AP2M1 Polyclonal Antibody

Name: AP2M1 Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-85381
Price: 5081.00 CNY
Availability: InStock

1 篇参考文献

查看其他22个AP2M1抗体

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

Additional Information:

抗体检测数据 (2)

图: 1 / 2

AP2M1 Antibody (PA5-85381) in WB

Western Blot using AP2M1 Polyclonal Antibody (Product # PA5-85381). Sample (50 µg of whole cell lysate). Lane A: mouse brain. 10% SDS PAGE. AP2M1 Polyclonal Antibody (Product # PA5-85381) diluted at 1:500.

Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

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产品信息

PA5-85381

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

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产品规格

种属反应

Human, Mouse

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein encompassing a sequence within the center region of human AP2M1. The exact sequence is proprietary.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

100 µg

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 20% glycerol

内含物

0.025% ProClin 300

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2792523

产品详细信息

Keep as concentrated solution.

Predicted reactivity: Mouse (100%), Rat (100%), Xenopus laevis (98%), Dog (100%), Pig (98%), Chicken (98%), Rhesus Monkey (98%), Chimpanzee (99%), Bovine (100%).

Positive Control: HepG2, mouse brain.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

The heterotetrameric coat assembly protein complex, also known as the adaptor-related protein complex 2 (AP-2), belongs to the adaptor complexes medium subunits family. The mu 1 subunit of the AP-2 complex (AP2M1) is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. AP2M1 has also been shown to associate with the HIV-1 protein Nef, suggesting that Nef may use AP-2 complex to enhance the rate of endocytosis of both CD4 and class I MHC. AP2M1 may also play an important role in regulating the intracellular trafficking and function of cytotoxic T-lymphocyte associated (CTLA)-4 protein. At least two isoforms of AP2M1 are known to exist.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: adapter-related protein complex 2 mu subunit; adaptin-mu2; adaptor protein complex AP-2 subunit mu; adaptor protein complex AP-2, mu1; adaptor related protein complex 2 mu 1 subunit; adaptor-related protein complex 2 subunit mu; adaptor-related protein complex AP-2, mu1; AP-2 mu 2 chain; AP-2 mu chain; clathrin adaptor complex AP2, mu subunit; clathrin assembly protein complex 2 medium chain; clathrin assembly protein complex 2 mu medium chain; clathrin coat adaptor protein AP50; clathrin coat assembly protein AP50; clathrin coat-associated protein AP50; clathrin-associated AP-2; clathrin-associated/assembly/adaptor protein, medium 1; HA2 50 kDA subunit; KIAA0109; mu2-adaptin; plasma membrane adaptor AP-2 50 kDa protein; plasma membrane adaptor AP-2 50kDA protein; unnamed protein product

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基因别名: AP50; CLAPM1; MRD60; mu2

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UniProt ID: (Human) Q96CW1, (Mouse) P84091

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Entrez Gene ID: (Human) 1173, (Mouse) 11773

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功能

signal sequence binding protein binding clathrin adaptor activity ion channel binding low-density lipoprotein particle receptor binding disordered domain specific binding

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