Invitrogen

AP2S1 Recombinant Rabbit Monoclonal Antibody (K01_3J85)

Name: AP2S1 Recombinant Rabbit Monoclonal Antibody (K01_3J85)
Brand: Invitrogen
SKU: MA564315

查看其他8个AP2S1抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (1)

图: 1 / 1

AP2S1 Antibody (MA564315) in WB

Western blot analysis of AP2S1 in various lysates. Samples were incubated with AP2S1 recombinant monoclonal (Product # MA564315). Samples: SH-SY5Y, 293T lysates.

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产品信息

MA564315

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293F

分类

Recombinant Monoclonal

类型

Antibody

克隆号

K01_3J85

抗原

Peptide.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A/G

保存液

50mM tris glycine, pH 7.4, with 150mM NaCl, 0.05% BSA, 40% glycerol

内含物

0.01% sodium azide

保存条件

Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C

运输条件

Ambient (domestic); Wet ice (international)

AB_3705363

靶标信息

Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif. May also play a role in extracellular calcium homeostasis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: adapter-related protein complex 2 sigma subunit; adapter-related protein complex 2 subunit sigma; Adaptor protein complex AP-2 subunit sigma; adaptor-related protein complex 2 sigma 1 subunit; Adaptor-related protein complex 2 subunit sigma; adaptor-related protein complex 2, sigma 1 subunit; AP-2 complex subunit sigma; AP17-DELTA; Clathrin assembly protein 2 sigma small chain; clathrin assembly protein 2 small chain; Clathrin coat assembly protein AP17; Clathrin coat-associated protein AP17; clathrin-associated protein 17; clathrin-associated/assembly/adaptor protein, small 2 (17kD); HA2 17 kDa subunit; Plasma membrane adaptor AP-2 17 kDa protein; Sigma-adaptin 3b; Sigma2-adaptin

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基因别名: AI043088; AP17; AP2S1; CLAPS2; FBH3; FBHOk; HHC3

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UniProt ID: (Human) P53680, (Rat) P62744, (Mouse) P62743

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Entrez Gene ID: (Human) 1175, (Rat) 65046, (Mouse) 232910

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功能

transporter activity protein binding protein transporter activity clathrin adaptor activity molecular_function vesicle coat protein

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